Effect of Yishen Huayu Prescription on Th17/Treg cell balance and estrogen-progestogen in patients with unexplained recurrent spontaneous abortion
Objective To study the effect of Yishen Huayu Prescription on T helper cell 17(Th17)/regulatory T(Treg)cell balance and estrogen-progesterone in patients with unexplained recurrent spontaneous abortion(URSA).Methods Ninety-two patients with URSA were randomly divided into treatment group(46 cases)and control group(46 cases).All pa-tients were given routine Western medicine(RWM),those in the treatment group were additionally given Yishen Huayu Prescrip-tion.A 12-week treatment was performed in both groups.The traditional Chinese medicine(TCM)syndrome score,Th17/Treg cells level,Th17/Treg related cytokines levels(Interleukin-17A[IL-17A],IL-35,transforming growth factor-β1[TGF-β1]),female hormone level(estradiol[E2],progesterone[P],β-human chorionic gonadotropin[β-HCG]),curative effect of TCM syndrome,the success rate of fetal protection were included as comparators between groups.Results The total ef-fective ratein the treatment group was significantly higher than that of control group(95.65%[44/46]vs 82.61%[38/46],P<0.05).After treatment,the dimension score and total score of TCM syndrome in the both groups were significantly lower than those before treatment,and the decreases were more common in the treatment group relative to the control group(P<0.05).After treatment,Th17 cells and Th17/Treg in the both groups were sig-nificantly lower than those before treatment,while Treg cells was significantly higher(P<0.05),and the treatment group was su-perior to the control group for the levels of Th17 cells,Th17/Treg,Treg cells.After treatment,IL-17A in the two groups was significantly lower than that before treatment(P<0.05),while IL-35 and TGF-β1 were significantly higher(P<0.05).There were significant differences in serum levelsof IL-17A,IL-35 and TGF-β1 between the treatment group and the control group after treatment(P<0.05).E2,P,β-HCG in the both groups were significantly higher than those before treatment,the increases were more pronounced in the treatment group compared to the control group(P<0.05).The success rate of fetal pro-tection in the treatment group was significantly higher than that of control group(84.78%[39/46]vs 65.22%[30/46],P<0.05).Conclusion Yishen Huayu Prescription in treating URSA can improve the clinical symptoms and therapy effect,which may promote secretion of estrogen-progesterone by correcting Th17/Treg cell imbalance.
Unexplained recurrent spontaneousabortionTraditional Chinese medicine therapyTh17/Treg cellsEstro-gen-progestogen
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