Effect of Simiao Pills combined with quadriceps functional exercise on functional recovery and inflammatory response in patients with knee osteoarthritis of damp-heat type
Objective To investigate the effect of Simiao Pills combined with quadriceps functional exercise in patients with knee osteoarthritis(KOA).Methods Eighty-four KOA patients(damp-heat type)were randomly assigned to receive quadriceps functional exercise(the control group,n=42)or Simiao Pills plus quadriceps functional exercise(the treatment group,n=42).Both groups were treated for4 weeks.The aim was to compare the scores of Western Ontario and McMaster Uni-versities Osteoarthritis Index(WOMAC)and the visual analogue scale(VAS),the levels of inflammatory factors(interleukin-1β[IL-1β]and interleukin-6[IL-6])before and after treatment between groups.The curative effects of the two groups were statistically analyzed.Results The overall effective rate of treatment group was significantly higher than that of control group(92.86%[39/42]vs76.19%[32/42],P<0.05).After treatment,the scores of WOMAC and VAS,and the levels of IL-1β and IL-6 in the both groups were significantly lower than those before treatment(P<0.05),and the decreases were more obviously in the treatment group compared to the control group(P<0.05).Conclusion Simiao Pills combined with quadriceps functional exercise has obvious curative effect in the treatment of KOA(damp-heat type),which can not only relieve pain,but also rapidly subside of inflammatory response,with sig-nificant effect in the medium and long term.
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