Objective To observe the effects of oral and external application of Yishen Zhuanggu Decoction on pain se-verity and joint function in patients with knee osteoarthritis(KOA).Methods A total of 88 KOA patients were randomly as-signed to receive either oral Yishen Zhuanggu Decoction(control group,n=44)or oral and external application of Yishen Zhuanggu Decoction(treatment group,n=44).The treatment continued for 2 courses(1 course for 10 days),the aim was to compare visual analogue scale(VAS)for pain,the American Knee Society Score(KSS),activities of daily living(ADL)scale,Interleukin 1β(IL-1β),matrix metalloproteinase-3(MMP-3),MMP-13.The curative effect and adverse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(90.91%[40/44]vs 72.73%[32/44],[P<0.05],respectively).After treatment,the VAS scores were significantly lower in both groups than that before treatment(P<0.05),the scores of KSS and ADL were significantly higher in both groups than those before treatment(P<0.05),the levels of IL-1β,MMP-3 and MMP-13 in both groups were significantly decreased than those before treat-ment(P<0.05),and the improvements were more pronounced in the treatment group than those of the control group(all P<0.05).The difference was not statistically significant in the total incidence of adverse reactions between the treatment group and the control group(2.27%[1/44]vs 6.82%[3/44],[P>0.05],respectively).Conclusion For KOA patients,oral and external application of Yishen Zhuanggu Decoction can effec-tively relieve knee joint pain and promote recovery of joint function.
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