Effects of oral and external application of Yishen Zhuanggu Decoction on pain severity and joint function in patients with knee osteoarthritis
Objective To observe the effects of oral and external application of Yishen Zhuanggu Decoction on pain se-verity and joint function in patients with knee osteoarthritis(KOA).Methods A total of 88 KOA patients were randomly as-signed to receive either oral Yishen Zhuanggu Decoction(control group,n=44)or oral and external application of Yishen Zhuanggu Decoction(treatment group,n=44).The treatment continued for 2 courses(1 course for 10 days),the aim was to compare visual analogue scale(VAS)for pain,the American Knee Society Score(KSS),activities of daily living(ADL)scale,Interleukin 1β(IL-1β),matrix metalloproteinase-3(MMP-3),MMP-13.The curative effect and adverse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(90.91%[40/44]vs 72.73%[32/44],[P<0.05],respectively).After treatment,the VAS scores were significantly lower in both groups than that before treatment(P<0.05),the scores of KSS and ADL were significantly higher in both groups than those before treatment(P<0.05),the levels of IL-1β,MMP-3 and MMP-13 in both groups were significantly decreased than those before treat-ment(P<0.05),and the improvements were more pronounced in the treatment group than those of the control group(all P<0.05).The difference was not statistically significant in the total incidence of adverse reactions between the treatment group and the control group(2.27%[1/44]vs 6.82%[3/44],[P>0.05],respectively).Conclusion For KOA patients,oral and external application of Yishen Zhuanggu Decoction can effec-tively relieve knee joint pain and promote recovery of joint function.
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