Effect of modified Shuyangquan Powder on postoperative immune function and vaginal microecology of patients with cervical squamous intraepithelial lesion and high-risk human papillomavirus of damp-heat type
Objective To explore the effect of modified Shuyangquan Powder on postoperative immune function and va-ginal microecology of patients with cervical squamous intraepithelial lesion(SIL)and high-risk human papillomavirus(HR-HPV)of damp-heat type.Methods A total of 112 patients with SIL and HR-HPV of damp-heat type underwent loop elec-trosurgical excision procedure(LEEP)were randomized1∶1 to treatment group(56 patients)or control group(56 patients).All patients were given recombinant human interferon alpha-2b(rhIFNalpha-2b)vaginal effervescent capsules,and those in the treatment group were additionally given modified Shuyangquan Powder.A 3-month consecutive treatment was performed,ai-ming to compare clinical efficacy,traditional Chinese medicine(TCM)syndrome score,immune function,vaginal microenviron-ment.Results Finally,there were 54 cases in the treatment group(2 cases of withdrew)and 52 cases in the control group completed the trial(2 cases of withdrew and 2 cases of missing case data),respectively.The total effective rate of the treatment group was better than that of the control group(92.59%[50/54]vs 73.08%[38/52],P<0.05).The 6-month dimension score and total scores of TCM syndrome in both groups were signif-icantly decreased than those before operation(P<0.05),and the 6-month dimension score and total scores of excessive,yellow or green,thick or foamy,and filthy or stinky in leucorrhea,and calor or itch in vulva in the treatment group were decreased than those of the control group(P<0.05).The 6-month levels of serum immunoglobulin(Ig)A,IgG,IgM,CD3+,CD4+,and CD4+/CD8+in both groups were significantly higher than those before operation,but CD8+level was lower(P<0.05).There were significant differences in the above indexes between groups(P<0.05).The6-month vaginal flora with a density-grade ofⅡ-Ⅲ,flora diversity-grade of Ⅱ-Ⅲ,Lactobacillus with a grade Ⅰ-Ⅱa in both groups were significantly increased than those before operation(P<0.05),but the pH value was significantly decreased(P<0.05),the improvements were more pro-nounced in the treatment group than those of the control group(all P<0.05).Conclusion For patients with SIL and HR-HPV of damp-heat type,modified Shuyangquan Powder can improve clinical symptoms,HR-HPV negative rate and treatment effect by improving immune function and regulating vaginal microecology.
Cervical squamousCervical neoplasiaPrecancerous conditionTraditional Chinese medicine therapy
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