Effects of self-made Yiqi Yangyin Huayu Decoction on postoperative cardiac function and vascular endothelial function in patients with coronary heart disease underwent percutaneous coronary intervention
Objective To observe the effects of self-made Yiqi Yangyin Huayu Decoction on postoperative cardiac function and vascular endothelial function in patients with coronary heart disease(CHD)underwent percutaneous coronary inter-vention(PCI).Methods Sixty-two CHD patients underwent PCI were included as the research subjects,and they were ran-domly classified into control group(n=31)and treatment group(n=31).All patients were given routine drug treatment(drugs of anti-platelet aggregation and stabilize plaque),and those in the treatment group were additionally given self-made Yiqi Yangyin Huayu Decoction.A 4-week treatment was performed.The traditional Chinese medicine(TCM)symptoms scores,vascular endothelial function(serum nitric oxide[NO],vascular endothelial growth factor[VEGF],endothelin-1[ET-1]),cardiac function(stroke volume[SV],left ventricular ejection fraction[LVEF],left ventricular end-systolic volume[LVESV],left ventricular end-diastolic diameter[LVEDD],left ventricular end-systolic diameter[LVESD]),and hemo-rheological indicators(whole blood viscosity[WBV],plasma viscosity[PV],hematocrit[Hct]and erythrocyte aggregation in-dex[AI])were compared between the two groups.The angina pectoris curative effect and the incidence of adverse events were assessed between the two groups.Results After treatment,the dimension scores and total scores of TCM symptoms(chest tightness and pain,palpitations and night sweats,five upsets and fever,and insomnia)in the both groups were significantly lower than those before treatment(P<0.05),and which in the treat-ment group were more lower relative to the control group(P<0.05).After treatment,the levels of NO and VEGF in both groups were significantly increased than those before treatment(P<0.05),but the levels of ET-1 in both groups were significantly de-creased(P<0.05),and the improvements in the treatment group were more common compared to the control group(all P<0.05).After treatment,the levels of LVEF and SV in the both groups were significantly increased than those before treatment(P<0.05),while the levels of LVEDD,LVESD and LVESV were significantly decreased(P<0.05),and the treatment group was superior to the control group for the levels of LVEF,SV,LVEDD,LVESD and LVESV(all P<0.05).After treatment,the levels of WBV,PV,Hct and AI in both groups were significantly lower than those before treatment(P<0.05),and the decrea-ses in the treatment group were more pronounced compared with the control group(P<0.05).The total effective rate of angina pectoris in the treatment group was significantly higher than that of the control group(87.10%[27/31]vs 64.52%[20/31],P<0.05),and there was no statistically significant difference in the incidence of adverse events between the treatment group and the control group(6.45%[2/31]vs 16.13%[5/31],P>0.05).Conclusion Self-made Yiqi Yangyin Huayu Decoction can effectively improve postoperative cardiac function and vascular endothelial function of CHD patients underwent PCI,and it does not increase the occurrence of adverse reactions.
Percutaneous coronary interventionCoronary heart diseaseTraditional Chinese medicine therapyCardiac function testVascular endothelial function
NETL
NSTL
万方数据
