Clinical effect of kidney-nourishing and blood-activating therapy combined with laparoscopy for repeated implant failure and endometriosis
Objective To observe the clinical effect of kidney-nourishing and blood-activating therapy combined with laparoscopy for repeated implant failure(RIF)and endometriosis(EMs).Methods A total of 72 RIF patients with EMs were randomly assigned into treatment group(n=36)and control group(n=36).All patients were managed by laparoscopy,and those in treatment group were additionally treated with kidney-nourishing and blood-activating therapy.The aim was to com-pare revised American Fertility Society(r-AFS)stages,traditional Chinese medicine(TCM)syndrome score,TCM curative effect,endometrial thickness on the day of endometrial transformation,serum beta human chorionic gonadotropin(β-hCG)af-ter embryo transfer,pregnancy outcome,as well as laboratory indexes.Results The age,body mass index(BMI),course for infertility or infertility,times of adverse pregnancy or transplantation failure were comparable between the two groups(P>0.05).There was no statistically significant difference in r-AFS stages between the two groups(P>0.05).After treatment,TCM symptom scores in the both groups were significantly de-creased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).The overall effective rate in the treatment group was better than that in the con-trol group(75.0%[27/36]vs 50.0%[17/34],P<0.05).The endometrial thickness was significantly higher in the treatment group than in the control group(P<0.05).The difference was statistically significant in β-hCG between groups(P<0.05).The implantation rate,clinical pregnancy rate,and ongoing pregnancy rate in the treatment group were better than those of the control group(P<0.05).The early abortion rate was slightly lower than that of the control group(P>0.05).After treatment,the percentage of natural killer(NK)cell in the both groups was significantly decreased(P<0.05),the decrease in the treatment group was more common than the control group(P<0.05).The levle of tumour necrosis factor alpha(TNF-α)in the both groups were significantly decreased than before treatment(P<0.05),but there was no significant statistical difference in TNF-α between groups(P>0.05).After treatment,interleu-kin 6(IL-6)in the treatment group was significantly lower than before treatment(P<0.05).Conclusio The kidney-nour-ishing and blood-activating therapy combined with laparoscopy in RIF patients with EMs can effectively improve TCM syndrome scores and endometrial thickness,reduce NK cell percentage,and reduce the levels of TNF-α and IL-6,but it has no signifi-cant effect on IL-10.Combined treatment is superior to laparoscopy alone for the rates of implantation,clinical pregnancy,and ongoing pregnancy,and it has a lower abortion rate.
EndometriosisImplantIntegrated traditional Chinese and Western medicine therapy