Clinical effect of acupoint application of Xuanwu Zhitong Paste combined with Yiqi Yangyin Jiedu Decoction on patients with cancer pain and its influence on quality of life
Objective To analyze the clinical effect of acupoint application of Xuanwu Zhitong Paste combined with Yiqi Yangyin Jiedu Decoction on patients with cancer pain and its influence on quality of life.Methods Sixty patients with cancer pain were randomly assigned to receive either three-step analgesic ladder(the control group,n=30)or acupoint application of Xuanwu Zhitong Paste combined with Yiqi Yangyin Jiedu Decoction(the treatment group,n=30).A 4-week treatment was performed.The pain relief time,duration of analgesic,number of breakthrough pain(BTP),pain mediator indexes,quality of life score were included as comparators.The analgesic effect and adverse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(90.00%[27/30]vs 66.67%[20/30],P<0.05).The pain relief time and the BTP frequency in the treatment group were significantly lower than those of the control group(P<0.05),and the duration of analgesia was significantly longer than that in the control group(P<0.05).After treatment,endothelin-1(ET-1)and neuropeptide Y(NPY)in the two groups decreased significantly than those before treatment,but β-endorphin(β-EP)increased significantly(all P<0.05),and the treatment group was superior to the control group for ET-1,NPY and β-EP(all P<0.05).After treatment,the quality of life score in the both groups was significantly higher than that before treat-ment(P<0.05),the improvement was more pronounced in the treatment group relative to the control group(P<0.05).The total incidence of adverse reactions was significantly lower in the treatment group than in the control group(P<0.05).Conclusion The acupoint application of Xuanwu Zhitong Paste combined with Yiqi Yangyin Jiedu Decoction has a significant analgesic effect in patients with cancer pain.It can effectively improve the levels of pain mediators,quickly and lastingly exert analgesic effects,re-duce BTP frequency,improve the quality of life,and with a high safety.
PainCancerComplicationAcupoint application therapyTraditional Chinese medicine therapy