Clinical observation of Qingwen Baidu Decoction on sepsis-associated acute respiratory distress syndrome
Objective To explore the therapeutic effect of Qingwen Baidu Decoction on sepsis-associated acute respir-atory distress syndrome(ARDS).Methods Seventy patients with sepsis-associated ARDS were divided into treatment group(n=35)and control group(n=35)by random number table.All Patients were given conventional symptomatic treatment,and patients in the treatment group were additionally treated with Qingwen Baidu Decoction.After 7 days of treatment,changes in blood gas index,inflammation index,Sequential Organ Failure Assessment(SOFA)score,Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ)score,and Murray lung injury score were compared.The length of mechanical ventilation and stay in intensive care unit(ICU)were observed.Results After treatment,partial pressure of arterial oxygen(PaO2),arterial oxy-gen partial pressure to inspired oxygen fraction ratio(PaO2/FiO2)in the two groups increased significantly than those before treatment(P<0.05),while arterial partial pressure of carbon dioxide(PaCO2)decreased significantly(P<0.05).The im-provements were better in treatment group than in control group(P<0.05).After treatment,the levels of serum procalcitonin(PCT),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the two groups were significantly decreased than those before treatment(P<0.05),and the decrease in the treatment group was more significant(P<0.05).After treatment,the scores of SOFA,APACHE Ⅱ and Murray lung injury in two groups were significantly lower,and which were significantly lower in treatment group than in control group(P<0.05).The length of mechanical ventilation and stay of ICU in treatment group were significantly shorter than those of control group(P<0.05).Conclusion Qingwen Baidu Decoction has a significant effect in treating sepsis-associated ARDS,which can improve oxygenation index,reduce serum in-flammatory index,reduce organ damage,shorten the length of mechanical ventilation and stay in ICU.
SepsisAcute respiratory distress syndromeTraditional Chinese medicine therapy
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