Clinical efficacy of Erchen Decoction combined with polyene phosphatidylcholine capsules on metabolic-associated fatty liver disease
Objective To observe the clinical efficacy of Erchen Decoction combined with polyene phosphatidylcholine capsules on metabolic-associated fatty liver disease(MAFLD).Methods A total of 196 patients with MAFLD were divided into control group(n=98)and treatment group(n=98)according to a random number table.All patients were given routine guidance on diet and lifestylem,patients in the treatment group additonally received modified Erchen Decoction puls polyene phosphatidylcholine capsules.But those in the control group received the later only.A 12-week treatmeat was performed.The curative effects of the two groups were compared.The changes in body mass index(BMI)and waist circumference(WC),inde-xes of liver function and blood lipid,scores of B-ultrasound examination and traditional Chinese medicine(TCM)symptom be-fore and after treatment were included as comparators between the two groups.Results The total effective rate in the treatment group was significantly higher than that of the control group(90.81%[89/98]vs 76.53%[75/98],P<0.05).The levels of BMI in the treatment group at weeks 4,8 and 12 were signifi-cantly lower than those before treatment(P<0.05).The levels of BMI of the treatment group at weeks 8 and 12 were significantly lower than those at week 4(P<0.05).There was no significant difference in BMI level in the control group before and after treatment(P>0.05).The improvement of BMI in the treatment group was significantly better than that of the control group(P<0.05).The levels of WC in the two groups after treatment were significantly lower than those before treatment(P<0.05).The levels of alanine aminotransferase(ALT),aspartate aminotrans-ferase(AST),gamma-glutamyltransferase(γ-GT)in the two groups at weeks 4,8 and 12 were significantly lower than those before treatment(P<0.05).The levels of ALT at weeks 4,8 and12 in the treatment group were significantly lower than those of the control group(P<0.05).The levels of AST at weeks8 and12 in the treatment group were significantly lower than those of the control group(P<0.05).The levels of total cholesterol(TC)and triglycerides(TG)in the two groups at weeks 4,8 and 12 were lower than those before treatment(P<0.05),but the levels of high-density lipoprotein cholesterol(HDL-C)were higher(P<0.05).The levels of TC and TG at weeks 4,8 and 12 in the treatment group were lower than those of the control group(P<0.05),but the levels of HDL-C at weeks 8 and 12 in the treatment group were higher than those of the control group(P<0.05).After treatment,the scores of B-ultrasound examination and TCM symptom in the two groups were lower than those before treatment(P<0.05),and the decreases in the treatment group were more significant(P<0.05).Conclu-sion Erchen Decoction combined with polyene phosphatidylcholine capsule in the treatment of MAFLD can reduce BMI,reduce WC,improve liver function and blood lipid level,and improve score of B-ultrasound examination and TCM symptoms.
Liver disease,nonalcoholicIntegrative medicine therapy
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