Effect of Compound Zicao Oil on inflammatory reaction and growth factors in postoperative patients with anal fistula of damp-heat infusion type
Objective To study the effect of Compound Zicao Oil on inflammatory reaction and growth factors in postop-erative patients with anal fistula of damp-heat infusion type.Methods A total of 114 patients with anal fistula of damp-heat injection type were randomly divided into control group(n=57)and observation group(n=57).All patients were treated with burn ointment treatment,those in the observation group were additionally treated with Compound Zicao Oil.After 14 days of treatment,the clinical efficacy,traditional Chinese medicine(TCM)syndrome score,inflammatory factors,growth factor level,and treatment safety between groups were evaluated.Results The total effective rate of the observation group was higher than that of the control group(92.98%[53/57]vs 77.19%[44/57],P<0.05).After treatment,the TCM symptom scores in the both groups were lower than those before treatment(P<0.05),which in the observation group were more common relative to the con-trol group(P<0.05).After treatment,the levels of serum amyloid A(SAA),interleukin-14(IL-14)and Toll-like recep-tor 9(TLR-9)in the both groups were lower than those before treatment(P<0.05),which in the observation group were more pronounced compared to the control group(P<0.05).After treatment,vascular endothelial growth factor(VEGF),basic fibro-blast growth factor(bFGF)and transforming growth factor-β1(TGF-β1)in the both groups were higher than those before treatment(P<0.05),which in the observation group were more prevalent compared with the control group(P<0.05).During the treatment,the incidence of adverse reactions in the two groups was similar(P>0.05).Conclusion Compound Zicao Oil has a good therapeutic effect in patients with anal fistula of damp-heat infusion type,which can improve the main TCM symp-tom,and it can inhibit inflammatory reaction rate,increase growth factor level,and it has good therapeutic safety.
Anal fistuladifferentiation typesZicaoTraditional Chinese medicine therapy
NETL
NSTL
万方数据
