Effect of Shenqi Yizhu Decoction on tumor markers and quality of life of patients with advanced gastric cancer
Objective To observe the effect of Shenqi Yizhu Decoction on tumor markers and quality of life of patients with advanced gastric cancer(AGC).Methods A total of 94 AGC patients were randomly assigned to treatment group(n=47)or control group(n=47).All patients were managed by chemotherapy with docetaxel+cisplatin+5-fluorouracil(DCF)regimen,and those in treatment group were additionally treated with Shenqi Yizhu Decoction.The treatment continued for 3 cour-ses(1 course for 21 days),the aim was to compare traditional Chinese medicine(TCM)syndrome score,tumor markers(carci-noembryonic antigen[CEA],carbohydrate antigen 199[CA199],and carbohydrate antigen 724[CA724]),immune function indexes(complement C3,complement C4,CD40 cell),Eastern Cooperative Oncology Group(ECOG)score.The curative effect and safety were assessed.Results The overall effective rate in the treatment group was better than that of the control group(82.98%[39/47]vs 63.83%[30/47],P<0.05).After treatment,TCM symptom scores in the both groups were signifi-cantly decreased(P<0.05),the decrease was notable in the treatment group compared with the control group(P<0.05).CEA,CA199 and CA724 in the both groups were significantly decreased(P<0.05),the decreases in the treatment group were more common than the control group(P<0.05).The complement levels of C3,C4,and CD40 in the both groups were signifi-cantly decreased(P<0.05),which were significantly lower in the treatment group relative to the control group(P<0.05).ECOG scores in the both groups were significantly decreased(P<0.05),the decrease in the treatment group was more prevalent compared to the control group(P<0.05).The incidence of adverse reactions in the treatment group was comparable to that in the control group(19.15%[9/47]vs 14.89%[7/47],P>0.05).Conclusion For AGC patients,Shenqi Yizhu Decoction has good therapeutic effects,which can improve TCM syndromes,reduce tumor marker levels,improve immune function,de-crease ECOG scores,and with good treatment safety.
Advanced gastric cancerShenqi Yizhu DecoctionTraditional Chinese medicine syndrome scoreTumor markersImmune function
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