Clinical efficacy of Shouhui Tongbian capsule combined with Ginseng Guben oral liquid for cancer-related fatigue pa-tients with constipation
Objective To observe the clinical efficacy of Shouhui Tongbian capsule combined with Ginseng Guben oral liquid for cancer-related fatigue(CRF)patients with constipation.Methods A total of 96 CRF patients with constipation were randomly assigned into treatment group(n=48)and control group(n=48).All patients were managed by lactulose oral solu-tion,and those in treatment group were additionally treated with Shouhui Tongbian capsule combined with Ginseng Guben oral liquid.The treatment continued 1 week to compare clinical symptoms,constipation symptoms,gastrointestinal motility function.The curative effect was assessed.Results The overall effective rate in the treatment group was better than that in the control group(95.83%[46/48]vs 79.71%[38/48],P<0.05).After treatment,first defecation time and defecation interval time in the both groups were significantly shorter than those before treatment,but the Cleveland Clinic Score(CCS),stool texture score were significantly lower(all P<0.05),and the different was significant in the above indexes between groups(all P<0.05).The scores of rectal symptoms,abdominal symptoms,and Bristol Stool Scale(BBS)in the both groups were signifi-cantly decreased,the decrease in the treatment group was more prevalent compared to the control group(P<0.05).The mini-mum sensitivity and compliance of rectal in the both groups were significantly decreased,which decreased notably in the treatment group relative to the control group(P<0.05).Conclusion Shouhui Tongbian capsule combined with Ginseng Guben oral liq-uid can improve constipation in CRF patients.
FatigueTumor complicationConstipationTraditional Chinese medicine therapy