Clinical practice of humidification intervention of Qingre Jiedu Decoction in preventing ventilator-associated pneumo-nia in ICU patients
Objective To investigate the clinical effect of humidification intervention of Qingre Jiedu Decoction in the prevention of ventilator-associated pneumonia(VAP)in intensive care unit(ICU)patients.Methods Ninety-eight patients with mechanical ventilation in ICU of our hospital from January 2022 to January 2023 were enrolled,and they were divided into observation group(n=49)and control group(n=49)according to a random number table.All patients were given routine hu-midification nursing(chlorhexidine),and those in the observation group were additionally given humidification nursing of Qingre Jiedu Decoction.The occurrence of VAP,hospitalization,and detection rate of pathogenic bacteria in oral secretions were com-pared before and after intervention between groups.The oral adverse events,blood gas analysis indexes,and inflammatory inde-xes were assessed.Results The incidence of VAP in the observation group was significantly lower than that in the control group(2.04%[1/49]vs 16.33%[8/49],χ2=5.995,P=0.014).After intervention,the incidence of gum swelling and bad breath in both groups was lower than before intervention,and which in the observation group was more pronounced compared to the control group(P<0.05).The length of hospital stay,ICU time and mechanical ventilation time in observation group were significantly shorter than those of control group(P<0.05).The detection rates of fungal spore mycelium,Gram-positive and Gram-negative pathogenic bacteria in observation group were significantly lower than those of the control group,but the detec-tion rate of oral normal bacteria was significantly higher(P<0.05).After intervention,the levels of arterial oxygen saturation(SaO2)and partial pressure of oxygen(PaO2)in the both groups were significantly higher than before intervention,whereas the lev-el of arterial carbon dioxide tension(PaCO2)was significantly lower than before intervention,the observation group was superior to the control group for the level of SaO2,PaO2 and PaCO2(P<0.05).After intervention,the levels of white blood cell(WBC),C-reactive protein(CRP),and procalcitonin(PCT)in the both groups were lower than before intervention,and the decrease in observation group was more common compared to the control group(P<0.05).Conclusion The humidification in-tervention of Qingre Jiedu Decoction can effectively prevent the occurrence of VAP in ICU patients,improve the blood gas index,decrease oral adverse events,reduce the planting of pathogenic bacteria,shorten the treatment time,and it is more conducive to the recovery of patients.
Qingre Jiedu DecoctionHumidification interventionIntensive care unit(ICU)Ventilator-associated pneumoniaClinical effect
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