Clinical efficacy of Qingre Huayu Yangyin Formula combined with routine Western medicine on immune function and inflammatory response in children with Kawasaki disease
Objective To explore the clinical efficacy of Qingre Huayu Yangyin Formula combined with routine Western medicine for children with Kawasaki disease(KD),and its influence on immune function and inflammatory response.Methods A total of 147 children with KD in our hospital from January 2020 to December 2022 were enrolled and randomly assigned into the treatment group(n=70)and the control group(n=77).All patients were managed by routine Western medicine,and those in treatment group were additionally treated with Qingre Huayu Yangyin Formula.Treated for 2 weeks,the aim was to compare regression time of fever,hand and foot swelling,mucosal hyperemia,rash,lymph node enlargement,immune function indexes(t-lymphocyte subsets CD4+,CD8+,CD4+/CD8+,regulatory T cells[Treg],T helper 17 cells[Th17],Th17/Treg),in-flammatory factors(tumor necrosis factor alpha[TNF-ɑ],C-reactive protein[CRP],interleukin6[IL-6]).The curative effect and adverse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(91.43%[64/70]vs 77.92%[60/77],P<0.05).After treatment,t-lymphocyte subsets CD4+,CD4+/CD8+,Th17,Th17/Treg were significantly decreased in the two groups than those before treatment,but CD8+,Treg were sig-nificantly increased(all P<0.05),and the treatment group was superior to the control group for CD4+,CD4+/CD8+,Th17,Th17/Treg,CD8+,Treg(all P<0.05).The levels of TNF-ɑand IL-6 in the two groups after treatment were significantly decreased than those before treatment,but the levels of CRP were significantly increased(all P<0.05),and the treatment group was superior to the control group for the levels of TNF-ɑ,IL-6,CRP(all P<0.05).The overall incidence of adverse reac-tions during treatment in the treatment group was comparable to that in the control group(20.00%[14/70]vs 18.18%[14/77],P>0.05).Conclusion For children with KD,Qingre Huayu Yangyin Formula combined with routine Western med-icine has significant clinical efficacy,which can accelerate the disappearance of clinical symptoms by regulating immune function and reducing inflammation levels.No obvious adverse reactions is found,and it has a high safety.
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