Influence of Modified Chushao Liangxue Decoction on immune function and Th17-related factors in psoriasis vulgaris
Objective To observe the clinical efficacy of modified Chushao Liangxue Decoction for psoriasis vulgaris(PV)and its on immune function and T helper cell 17(Th17)-related factors.Methods A total of 64 patients with progres-sive PV treated in our hospital from February 2020 to December 2021 were randomly1:1assigned to control group(conventional Western medicine)or observation group(Modified Chushao Liangxue Decoction).The treatment period was 6 weeks,and the peripheral blood T lymphocytes subsets,isolated peripheral blood mononuclear cell(PBMC)were detected,aim to analyze the expression of interleukin-17(IL-17),IL-22,retinoic acid receptor-related orphan receptor gamma(ROR-γ)mRNA,interferon gamma(INF-γ)mRNA in PBMC,and assess the curative effect.Results After 6-week of treatment,the overall effective rate in the observation group was better than that in the control group(93.75%[30/32]vs 75.00%[24/32],P<0.05).After 6-week of treatment,CD3+,CD4+,CD4+/CD8+T lymphocytes in the both groups were significant increased than those before treatment,while CD8+,IL-17,IL-22,ROR-γ mRNA,INF-γ mRNA were significant decreased.The inter-group differences were significant at different time points(P<0.05).Conclusion Modified Chushao Liangxue Decoc-tion has effective therapeutic effects in PV patients,it can improve immune function,reduce adverse symptoms,and improve clinical efficacy.Its mechanism may be related to the distribution of T lymphocyte subsets and Th17-related factors.
PsoriasisTraditional Chinese medicine therapyImmune functionT lymphocytes subsets
NETL
NSTL
万方数据
