Effect of Peiyuan Kangai Decoction combined with docetaxel and cisplatin regimen on traditional Chinese medicine symptoms and immune function in advanced esophageal cancer
Objective To study the effect of Peiyuan Kangai Decoction combined with docetaxel and cisplatin(DP)regimen on traditional Chinese medicine(TCM)symptoms and immune function in advanced esophageal cancer.Methods A total of 104 patients with advanced esophageal cancer were randomly divided into control group(n=52)and treatment group(n=52).All patients were treated with DP chemotherapy scheme,those in the treatment group were additionally treated with Peiyuan Kangai Decoction.After 3 courses of treatment(3 weeks as a treatment course),the clinical efficacy,TCM symptom score,immune function index in the two groups were evaluated,the level of serum marker proteins and the occurrence of adverse reactions in the two groups were observed.Results The objective remission rate(ORR:71.15%[37/52]vs 51.92%[27/52])and disease control rate(DCR:84.62%[44/52]vs 67.31%[35/52])in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the TCM symptoms scores(including dry mouth and throat,choking swelling and pain,mental fatigue and breath shortness,yellow face and weight loss)in the both groups were significantly lower than before treatment(P<0.05),the decreases were more common in the treatment group relative to the control group(P<0.05).The levels of CD3+,CD4+and CD4+/CD8+in the both groups were significantly higher than before treatment(P<0.05),but CD8+level was significantly lower(P<0.05),the improvements were better in treatment group than in con-trol group(P<0.05).After treatment,the levels of mitogen-activated protein kinase(MAPK),caspase-3 and B cell activating factor receptor(BAFF-R)in the two groups were sig-nificantly decreased than those before treatment(P<0.05),and the decrease in the treatment group was more significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Peiyuan Kangai Decoction combined with DP regimen has good therapeutic effect in the treatment of advanced esophageal cancer.It can improve the TCM symptoms,improve the immune function,inhibit the expression level of MAPK,Caspase-3,BAFF-R and serum marker proteins.It has good therapeutic safety.
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