Efficacy of Jiejing Decoction combined with dezocine injection in treating spontaneous subarachnoid hemorrhage and its influences on serum sFlt-1 and sICAM-1
Objective To investigate the curative effect of Jiejing Decoction combined with dezocine injection in treating spontaneous subarachnoidhemorrhage(sSAH)andits influences onserumsoluble fms-like tyrosinekinase-1(sFlt-1)and soluble intercellular cell adhesion molecule-1(sICAM-1).Methods Eighty-eight sSAH patients were randomly grouped into the control group(n=44)and the combined group(n=44).All patients were given intramuscular injection of dezocine,and those in the combined group were additionally given Jiejing Decoction.A 14-day treatment was performed in the both groups.The clinical efficacy was compared between groups.Before treatment,7 days of treatment,and after treatment,the inci-dence of the mean blood flow velocity(MBF)and cerebral vasospasm(CV)of the middle cerebral artery were recorded.The in-dicators of oxidative stress,the levels of vascular endothelial damage factors,the scores of National Institutes of Health Stroke Scale(NIHSS),Glasgow Coma Scale(GCS),and Mini-Mental State Examination(MMSE),as well as the incidence of adverse reactions were included as comparators.Results The total effective rate of the combined group was significantly better than that of the control group(95.45%[42/44]vs 79.55%[35/44],P<0.05).The incidences of MBF and CV in the combined group were significantly lower than those of the control group after 7 days of treatment and after treatment(P<0.05).After treatment,the serum levels of reduced glutathione(GSH)and superoxide dismutase(SOD)in the both groups were significantly higher than those before treatment(P<0.05),but the levels of malondialdehyde(MDA)were significantly lower(P<0.05),the improvement was more pronounced in the combined group relative to the control group(P<0.05).After treatment,the lev-els of serum sFlt-1 and sICAM-1 in the both groups were obviously lower than those before treatment(P<0.05),the de-crease was more common in the combined group compared to the control group(P<0.05).After treatment,the NIHSS scores of the both groups were significantly lower than those before treatment(P<0.05),while the GCS score and MMSE score were sig-nificantly higher(P<0.05),the combined group was superior to the control group for the score of NIHSS,GCS,and MMSE.There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Con-clusion Jiejing Decoction combined with dezocine injection in the treatment of sSAH can reduce the incidence of cerebral vaso-spasm,improve cerebral blood flow,oxidative stress and vascular endothelial injury,and promote the recovery of neurological function.
Subarachnoid hemorrhageTraditional Chinese medicine therapyIntegrative medicine therapy
NETL
NSTL
万方数据
