Clinical efficacy of oral Xuanbi Jianxi Decoction combined with needling tendon method for knee osteoarthritis
Objective To observe the clinical efficacy of oral Xuanbi Jianxi Decoction combined with needling tendon method for knee osteoarthritis(KOA).Methods A total of 115 KOA patients were randomly assigned into the treatment group(n=58)and the control group(n=57).All patients were managed by conventional Western medicine,and those in the treat-ment group were additionally treated with Xuanbi Jianxi Decoction combined with needling tendon method.After 4 weeks,the aim was to compare the Western Ontario and McMaster Universities Osteoarthritis index(WOMAC),knee joint function(Le-quesne Algofunctional index score),bone metabolism indexes(osteoprotegerin[OPG],bone gla protein[BGP]),inflammatory factors(interleukin 6[IL-6],interleukin 1β[IL-1β],tumor necrosis factor alpha[TNF-α]).The curative effect and ad-verse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(91.38%[53/58]vs 77.19%[44/57],[P<0.05],respectively).The difference was not statistically significant in the inci-dence of adverse reactions between the treatment group and the control group(10.34%[6/58]vs 10.53%[6/57],[P>0.05],respectively).After treatment,WOMAC scores(Joint stiffness,pain,physiological function)in the both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).Lequesne Algofunctional index score in the both groups was significantly decreased(P<0.05),which was significantly lower in the treatment group than in the control group(P<0.05).OPG and BGP in the both groups were significantly increased(P<0.05),the increase in the treatment group was more prevalent compared with the control group(P<0.05).IL-6,IL-1β,TNF-α in the both groups was significantly decreased(P<0.05),the decrease in the treatment group was more common than the control group(P<0.05).Conclusion For KOA patients,oral Xuanbi Jianxi Decoction combined with needling ten-don method can effectively control clinical symptoms,promote knee joint function recovery,improve bone metabolism,inhibit the expression of inflammatory factors,and with high safety.
Knee osteoarthritisTraditional Chinese medicine therapyNeedling tendon method
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