摘要
目的 观察宣痹健膝汤内服联合经筋刺法治疗膝骨关节炎(KOA)的临床疗效.方法 将115 例KOA患者按照随机数字表法分为对照组(57 例)和治疗组(58 例),对照组予常规西药治疗,治疗组在对照组基础上予宣痹健膝汤内服联合经筋刺法治疗,治疗4 周后统计2 组临床疗效及不良反应发生情况.比较 2 组治疗前后西安大略和麦克马斯特大学(WOMAC)骨关节炎指数量表评分、膝关节功能[奎森功能演算指数(Lequesne)评分]及骨代谢指标[骨保护素(OPG)、骨钙素(BGP)]、炎症因子[白细胞介素6(IL-6)、白细胞介素1β(IL-1β)和肿瘤坏死因子α(TNF-α)]水平变化情况.结果 治疗组总有效率91.38%(53/58),不良反应发生率10.34%(6/58),对照组分别为77.19%(44/57)、10.53%(6/57),治疗组总有效率高于对照组(P<0.05),2 组不良反应发生率比较差异无统计学意义(P>0.05).治疗后,2 组WOMAC骨关节炎指数量表关节僵硬、疼痛、生理功能评分及总分均较本组治疗前降低(P<0.05),且治疗组均低于对照组(P<0.05).治疗后,2 组Lequesne评分均较本组治疗前降低(P<0.05),且治疗组低于对照组(P<0.05).治疗后,2 组OPG、BGP水平均较本组治疗前升高(P<0.05),且治疗组高于对照组(P<0.05).治疗后,2 组IL-6、IL-1β、TNF-α水平均较本组治疗前下降(P<0.05),且治疗组均低于对照组(P<0.05).结论 宣痹健膝汤内服联合经筋刺法可有效控制KOA患者临床症状,促进膝关节功能恢复,还可改善其骨代谢水平,抑制炎症因子表达,且用药安全性高.
Abstract
Objective To observe the clinical efficacy of oral Xuanbi Jianxi Decoction combined with needling tendon method for knee osteoarthritis(KOA).Methods A total of 115 KOA patients were randomly assigned into the treatment group(n=58)and the control group(n=57).All patients were managed by conventional Western medicine,and those in the treat-ment group were additionally treated with Xuanbi Jianxi Decoction combined with needling tendon method.After 4 weeks,the aim was to compare the Western Ontario and McMaster Universities Osteoarthritis index(WOMAC),knee joint function(Le-quesne Algofunctional index score),bone metabolism indexes(osteoprotegerin[OPG],bone gla protein[BGP]),inflammatory factors(interleukin 6[IL-6],interleukin 1β[IL-1β],tumor necrosis factor alpha[TNF-α]).The curative effect and ad-verse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(91.38%[53/58]vs 77.19%[44/57],[P<0.05],respectively).The difference was not statistically significant in the inci-dence of adverse reactions between the treatment group and the control group(10.34%[6/58]vs 10.53%[6/57],[P>0.05],respectively).After treatment,WOMAC scores(Joint stiffness,pain,physiological function)in the both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).Lequesne Algofunctional index score in the both groups was significantly decreased(P<0.05),which was significantly lower in the treatment group than in the control group(P<0.05).OPG and BGP in the both groups were significantly increased(P<0.05),the increase in the treatment group was more prevalent compared with the control group(P<0.05).IL-6,IL-1β,TNF-α in the both groups was significantly decreased(P<0.05),the decrease in the treatment group was more common than the control group(P<0.05).Conclusion For KOA patients,oral Xuanbi Jianxi Decoction combined with needling ten-don method can effectively control clinical symptoms,promote knee joint function recovery,improve bone metabolism,inhibit the expression of inflammatory factors,and with high safety.
基金项目
邢台市科学技术局邢台市重点研发计划自筹项目(2021ZC076)
国家科技期刊平台
NSTL
万方数据