Clinical efficacy of Huangdi internal acupuncture combined with bismuth quadruple therapy on chronic atrophic gastri-tis with Helicobacter pylori infection and its influence on intestinal microecology and inflammatory factors
Objective This study aimed to assess the therapeutic efficacy of combining Huangdi internal acupuncture with bismuth quadruple therapy in patients with chronic atrophic gastritis(CAG)with Helicobacter pylori(HP)infection,and to explore its influence on intestinal microecology and inflammatory factors.Methods A total of 144 CAG patients with Hp infec-tion were recruited from our hospital and divided into the control group(n=72)and the treatment group(n=72)by a random number table.All patients received bismuth quadruple therapy,and those in the treatment group additionally received Huangdi internal acupuncture.The treatment duration was 2 weeks,aiming to compare the therapeutic efficacy,Hp eradication rate,treatment-emergent adverse event(TEAE),changs in inflammatory factors(including interleukin6[IL-6],IL-1β,tumor necrosis factor α[TNF-α])and intestinal microflora between groups before and after treatment.Results The total effective rates in the treatment group was significantly higher than that of the control group(88.89%[64/72]vs 72.22%[52/72],P<0.05).The Hp eradication rate in the treatment group was significantly higher than that of the control group(91.67%[66/72]vs 81.94%[59/72],P<0.05).After treatment,the serum levels of IL-1β,IL-6 and TNF-α significantly decreased in the both groups(P<0.05).However,the decrease in the treat-ment group was more pronounced relative to the control group(P<0.05).After treatment,the levels of Lactobacillus and Bifidobacterium significantly increased in the both groups,while the levels of Enterococcus,Enterobacter,Staphylococcus,and Clostridium perfringens decreased significantly(P<0.05).Im-portantly,the improvements in the treatment group were more common compared to the control group(P<0.05).There was no significant difference in TEAE between the treatment group and control group(8.33%[6/72]vs 6.94%[5/72],P>0.05).Conclusion The combination of Huangdi internal acupuncture and bismuth quadruple therapy demonstrates a clear therapeutic effect in CAG patients with Hp infection.It can increase Hp eradication rate,regulate intestinal flora,inhibit inflammation-re-lated factors level,and it is safe and reliable.
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