Mechanism of Yiqi Huatan Huoxue Formula in treating coronary heart disease based on network pharmacology
Objective To explore the mechanism of Yiqi Huatan Huoxue Formula in the treatment of coronary heart dis-ease by network pharmacology.Methods The components and targets of Yiqi Huatan Huoxue Formula were screened by the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform and the Bioinformatics Analysis Tool for Molecular mech-ANism of Traditional Chinese Medicine(BATMAN-TCM).The targets of coronary heart disease were searched in online data-bases.The common targets of Yiqi Huatan Huoxue Formula and coronary heart disease were obtained by plotting a Venn diagram,followed by an interaction analysis of compound-disease network was conducted by the STRING database.David database was used for gene ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis.Fi-nally,Cytoscape 3.82 was used to construct a drug-component-target-pathway-disease network.Results A total of 154 active ingredients and 71 targets of Yiqi Huatan Huoxue Formula were screened.The main active compounds included naringe-nin,quercetin,nobiletin and kaempferol,which were enriched in the regulation of lipids and atherosclerosis,Interleukin(IL)-17 signaling pathway,cell apoptosis,and fluid shear stress,and thus exerted the role in treating coronary heart disease.Conclu-sion Yiqi Huatan Huoxue Formula treats coronary heart disease in a multi-component,multi-target and multi-pathway mechanism.Our findings provide a theoretical basis for the basic or clinical research for Yiqi Huatan Huoxue Formula.
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