Clinical efficacy of modified Gujingcao mixture for children with Tourette's syndrome of liver exuberant and spleen weakness
Objective To observe the clinical efficacy of modified Gujingcao mixture for children with Tourette's syn-drome(TS)of liver exuberant and spleen weakness.Methods One hundred patients with TS of liver exuberant and spleen weakness were randomly assigned to receive either tiapride hydrochloride tablets(the control group,n=50)or modified Gujing-cao mixture(the treatment group,n=50).The treatment continued for 2 courses(1 course for 4 weeks),the aim was to com-pare Yale Global Tic Severity Scale(YGTSS),traditional Chinese medicine(TCM)symptom score,immunoglobulin A(IgA),IgG,IgM,zinc(Zn2+),calcium(Ca2+).Results After treatment,the domain scores(including sports tic,vocal tic and in-tegrated damage)and total scores of YGTSS in the both groups were significantly decreased(P<0.05),which decreased nota-bly in the treatment group compared with the control group(P<0.05).the domain scores(main symptom and secondary symp-tom)and total scores of TCM symptom and in the both groups were significantly decreased(P<0.05),which were significantly lower in the treatment group than in the control group(P<0.05).IgA,IgG and IgM in the both groups after treatment were sig-nificantly increased(P<0.05),the increase in the treatment group was more common than the control group(P<0.05).Zn2+and Ca2+in the both groups were significantly increased(P<0.05),the increase in the treatment group was more prevalent compared with the control group(P<0.05).Conclusion For TS patients of liver exuberant and spleen weakness,modified Gujingcao mixture can not only improve tic symptoms,but also improve the body's immune function,it can effectively promote the absorption of trace elements by improving the symptoms of spleen deficiency.
Multiple tics-coprolalia syndromePattern identificationTraditional Chinese medicine therapy
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