Clinical efficacy of Buqi Xiezhuo Decoction combined with sacubitril/valsartan on type 2 diabetic nephropathyof spleen-kidney qi deficiency
Objective To investigate the clinical efficacy of Buqi Xiezhuo Decoction combined with sacubitril/valsartan on type 2 diabetic nephropathy(DN)of spleen-kidney qi deficiency.Methods Eighty patients with type 2 DN were randomly assigned in a ratio assigned in a1∶1 ratio to sacubitril/valsartan(control group)or Buqi Xiezhuo Decoction+sacubitril/valsar-tan(treatment group)for 2 months.The aim was to compare renal function(blood urea nitrogen[BUN],serum creatinine[SCr],Cystatin C[Cys-C],β2-microglobulin[β2-MG],24-h urinary protein excretion,inflammatory cytokines[inter-leukin 17A[IL-17A],high-sensitivity C-reactive protein[hs-CRP],tumor necrosis factor-α[TNF-α]),traditional Chinese medicine(TCM)syndrome score.The curative effect and incidence of adverse reactions were assessed.Results The overall effective rate in the treatment group was better than that in the control group(90.0%[36/40]vs 72.5%[29/40],P<0.05).After treatment,BUN,SCr,Cys-C,β2-MG,24-h urinary protein excretion in the both groups were significantly de-creased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).IL-17A,hs-CRP and TNF-α levels in the both groups were significantly decreased(P<0.05),the decrease in the treatment group was more common relative to the control group(P<0.05).None of the incidence of adverse reactions differed significantly between groups(P>0.05).After treatment,TCM symptom scores in the both groups were significantly decreased(P<0.05),which were significantly lower in the treatment group compared to the control group(P<0.05).Conclusion Buqi Xiezhuo Decoction combined with sacubitril valsartan sodium tablets can effectively improve renal function,urine protein,TCM syndrome,decrease IL-17A,hs-CRP,TNF-α levels,and reduce inflammatory response in patients with type 2 DN(spleen-kidney qi deficiency).
Diabetic nephropathyInflammatory responseRenal functionIntegrative medicine
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