Effects of Huoxue Huayu Shengji Formula on intestinal flora,pepsinogen,esophageal motility,gastric mucosal injury repair in patients with gastroesophageal reflux diseaseof blood stasis type
Objective To observe the effects of Huoxue Huayu Shengji Formula on intestinal flora,pepsinogen,esopha-geal motility,gastric mucosal injury repair in patients with gastroesophageal reflux disease(GERD)of blood stasis type.Meth-ods A total of 115 GERD patients were randomly assigned in a1∶1 ratio to routine Western medicine(RWM,control group)or Huoxue Huayu Shengji Formula+RWM(treatment group)for 1 month.The aim was to compare serum pepsinogen I(PGI),transforming growth factor alpha(TGF-α),pepsinogen Ⅱ(PGⅡ),cholecystokinin(CCK),amount of Staphylococcus,Lac-tobacillus and Bifidobacterium,esophageal motility indexes(esophageal sphincter pressure,mean distal contractile integral[DCI],percentage total reflux time),traditional Chinese medi-cine(TCM)syndrome score,gastric acid output,gastric bile acid content,Reflux Disease Questionnaire(RDQ).The curative effect was assessed.Results The overall effective rate in the treatment group was better than that in the control group(96.55%[56/58]vs 82.46%[47/57],P<0.05).After treatment,significantly increased PGⅠand TGF-α levels,and decreased PGⅡ and CCK levels were found in the both groups than those before treatment(all P<0.05),and the different was significant between groups for the above indexes(all P<0.05).Signifi-cantly increased amount of Lactobacillus and Bifidobacterium,and decreased amount of Staphylococcus were detected in the both groups(all P<0.05),and the treatment group was superior to the control group for amount of Staphylococcus,Lactobacillus and Bifidobacterium(all P<0.05).Significantly higher esophageal sphincter pressure and mean DCI,and reducedproportion of total reflux timewere found in the both groups after treatment(all P<0.05),which were significantly pronounced in treatment group(all P<0.05).After treatment,TCM symptom scores in the both groups were significantly decreased(P<0.05),which de-creased notably in the treatment group compared with the control group(P<0.05).After treatment,gastric acid output,gastric bile acid content,RDQ score in the both groups were significantly decreased(P<0.05),which were significantly lower in the treatment group than in the control group(P<0.05).Conclusion Huoxue Huayu Shengji Formula can improve pepsinogen in-dicators,promote gastric mucosal injury repair,balance intestinal flora,improve esophageal motility,TCM syndromes and clini-cal symptoms,and enhance clinical efficacy in patients with GERD of blood stasis type.
Gastroesophageal reflux diseaseTraditional Chinese medicine therapyPepsinogenGastric mucosaIn-testinal floraEsophageal motility
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NSTL
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