Modulation effect of modified Jiegu Zhuanggu Formula supplemented by percutaneous vertebroplasty on postoperative lumbar spine function,rehabilitation process and osteoblast-osteoclast activity in osteoporotic vertebral compression fracture
Objective To investigate the effect of modified Jiegu Zhuanggu Formula supplemented by percutaneous ver-tebroplasty(PV)on postoperative lumbar spine function,rehabilitation process and osteoblast-osteoclast activity in osteoporotic vertebral compression fracture(OVCF).Methods Seventy patients with OVCF were randomized1∶1 to PV+routine Western medicine(RWM,the operation group)or modified Jiegu Zhuanggu Formula+PV+RWM(the combined group).The visual analog scale(VAS)for pain,Oswestry disability index(ODI),anatomical imaging(vertebral anterior height,intermediate ver-tebral height,Cobb's angle of injured vertebral),rehabilitation process(hospitalization time,postoperative ambulation time,fracture healing time,time to return to normal activities),osteoblast-osteoclast activity(osteocalcin,bone-specific alkaline phosphatase[BALP],procollagen type Ⅰ N-terminal propeptide[PⅠNP],Tartrate-resistant acid phosphatase[TRACP],the ratio of hydroxyproline/creatinine[OHP/Cr],bone mineral density[BMD]were included as comparators between groups.The efficacy and safety were statistically analyzed between groups.Results The total effective rate in the combined group was significantly higher than that of the operation group(97.14%[34/35]vs 77.14%[27/35],P<0.05).The VAS and ODI scores after treatment were significantly lower in the both group than those before treatment(P<0.05),with the inter-group significant difference(P<0.05).There was no significant difference in hospitalization time and postoperative ambulation time between groups(P>0.05),but the fracture healing time and time to return to normal activity time in the combined group were significantly shorter than those of the operation group(P<0.05).Af-ter treatment,significantly higher osteocalcin,PⅠNP,and BMD,and lower BALP,TRACP,and OHP/Cr were detected in the both groups than before treatment(P<0.05),with the inter-group significant difference(P<0.05).The anatomical imaging indexes were significantly lower in the both groups than before treatment(P<0.05),the combined group was superior to the op-eration group for the anatomical imaging indexes(P<0.05).The incidence of adverse reactions in the combined group was com-parable to the operation group(P>0.05).Conclusion Modified Jiegu Zhuanggu Formula supplemented by PV in the treatment of OVCF can relieve the patients'pain,improve lumbar function,promote bone formation,inhibit bone resorption,increase bone density,restore the anatomical structure of injured vertebra,enhance curative effect,it is safe and reliable.
NETL
NSTL
万方数据
