Effect of modified Shengjiang Powder combined with neoadjuvant chemotherapy with FOLFIRINOX in patients with lo-cally advanced pancreatic cancer
Objective To observe the effect of modified Shengjiang Powder combined with neoadjuvant chemotherapy with FOLFIRINOX(folinic acid,fluorouracil,irinotecan,and oxaliplatin)in patients with locally advanced pancreatic cancer(LAPC).Methods A total of 84 LAPC patients were randomly assigned into treatment group(n=42)and control group(n=42).All patients were managed by conventional therapy+neoadjuvant chemotherapy with FOLFIRINOX,and those in treatment group were additionally treated with modified Shengjiang Powder.The treatment continued for 6 chemotherapy cycles(1 cycles for 2 weeks),aiming to compare serum tumor markers(carcinoembryonic antigen[CEA],carbohydrate antigen 50[CA50],CA19-9,CA242),T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+),generic quality of life inventory-74(GQOL-74).The chemotherapy effect and adverse reactions were assessed.Results The objective remission rate in the treat-ment group was better than that in the control group(23.81%[10/42]vs7.14%[3/42],P<0.05).After treatment,CEA,CA50,CA19-9,CA242 in the both groups were significantly decreased(P<0.05),which were significantly lower in the treat-ment group than in the control group(P<0.05).Significantly increased CD3+,CD4+,CD4+/CD8+,and decreased CD8+were found in the both groups(all P<0.05),and the treatment group was superior to the control group for CD3+,CD4+,CD4+/CD8+,CD8+(all P<0.05).After treatment,the dimension score of GQOL-74 in the both groups were significantly increased(P<0.05),which was significantly higher in the treatment group than in the control group(P<0.05).The total in-cidence of adverse reactions in the treatment group was significantly lower than that in the control group(11.90%vs 35.71%,P<0.05).Conclusion Modified Shengjiang Powder combined with neoadjuvant chemotherapy with FOLFIRINOX can effec-tively control disease progression,enhance immunity,and improve quality of life in LAPC patients,and it had less adverse reactions and good prognosis.
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