Clinical efficacy of Fuling Gancao Mixture for chronic obstructive pulmonary disease with muscle attenuation
Objective To investigate the clinical efficacy of Fuling Gancao Mixture for chronic obstructive pulmonary disease(COPD)with muscle attenuation.Methods One hundred COPD patients with muscle attenuation were randomly assigned into treatment group(n=50)and control group(n=50).All patients were managed by conventional Western medicine,and those in treatment group were additionally treated with Fuling Gancao Mixture.A 3-month treatment was performed,the aim was to compare traditional Chinese medicine(TCM)syndrome score,pulmonary function indexes(forced expiratory volume in one second[FEV1],FEV1 percentage of predictive value[FEV1%pred],FEV1 to forced vital capacity ratio[FEV1/FVC]),muscle attenuation indexes(holding power,relative skeletal muscle mass index[RASM],walking speed),oxidative stress factors(superoxide dismutase[SOD],catalase[CAT],reactive oxygen species[ROS]),inflammatory factors(interleukin-1[IL-1],IL-8,tumor necrosis factor-alpha[TNF-α]),COPD Assessment Test(CAT),Nutritional Risk Screening 2002(NRS 2002),Activities of Daily Living Scale(ADL),adverse reactions.Results After treatment,TCM symptom(cough and shortness of breath,low voice,slow walking,fatigue,and muscle atrophy)scores in the both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).FEV1/FVC,FEV1%pred and FEV1 in the both groups were significantly increased(P<0.05),which were significantly higher in the treatment group than in the control group(P<0.05).The holding power,walking speed,RASM in the both groups were significantly increased(P<0.05),the increaseS in the treatment group were more prevalent compared with the control group(P<0.05).After treatment,the levels of SOD and CAT int the both groups significantly increased(P<0.05),but level of ROS significantly decreased(P<0.05),and the different was significant in the levels of SOD,CAT,and ROS between groups(P<0.05).The levels of IL-1,IL-8 and TNF-α in the both groups were significantly decreased(P<0.05),the decrease in the treatment group was more common than the control group(P<0.05).After treatment,the scores CAT and NRS 2002 significantly decreased in the two groups(P<0.05),but ADL scores significantly increased(P<0.05),and the treatment group was superior to the control group for the scores of CAT,NRS 2002 and ADL(all P<0.05).No adverse reaction in the treatment group was found,but there were adverse reactions in the control group,including 1 case of nausea and 2 cases of dizziness.Conclusion For COPD patients with muscle attenuation,Fuling Gancao Mixture can improve pulmonary function,inhibit oxidative stress and inflammatory reactions,improve clinical symptoms,delay muscle attenuation,improve exercise intensity and quality of life,and with high safety.
Pulmonary disease,chronic obstructiveTraditional Chinese medicine therapy
万方数据
维普
