首页|地黄饮子配合针刺对脑梗死恢复期患者认知功能、脑血流动力学及氧化应激的影响

地黄饮子配合针刺对脑梗死恢复期患者认知功能、脑血流动力学及氧化应激的影响

扫码查看
目的 观察地黄饮子合针刺对脑梗死恢复期患者认知功能、脑血流动力学、氧化应激及血清基质金属蛋白酶9(MMP-9)、基质金属蛋白酶组织抑制剂-1(TIMP-1)的影响.方法 选取 128 例脑梗死恢复期患者作为研究对象,按照掷硬币法分为2 组.2 组均予常规西药治疗,对照组61 例予常规针刺治疗,治疗组67 例在对照组治疗基础上加地黄饮子治疗.2 组均治疗3 个月后评价疗效.比较2 组治疗前后简易智力状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、脑血流动力学[颅内动脉的平均血流速度(Vm)、收缩期峰值流速(Vs)及搏动指数(PI)]、血清学指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、MMP-9、TIMP-1]水平.结果 治疗组总有效率95.52%(64/67),显著高于对照组的80.33%(49/61),比较差异有统计学意义(P<0.05).治疗后,2组MMSE、MoCA评分均上升(P<0.05),且治疗组高于对照组(P<0.05).治疗后,2 组Vm、Vs均上升(P<0.05),PI均下降(P<0.05),且2 组间比较差异均有统计学意义(P<0.05).治疗后,2 组SOD、GSH-Px水平均上升(P<0.05),且治疗组高于对照组(P<0.05);治疗后2 组MDA水平均下降(P<0.05),且治疗组低于对照组(P<0.05).治疗后,2 组MMP-9 水平均下降(P<0.05),且治疗组低于对照组(P<0.05);治疗后2 组TIMP-1 水平均上升(P<0.05),且治疗组高于对照组(P<0.05).结论 脑梗死恢复期患者采用地黄饮子合针刺治疗能够有效改善认知功能及脑血流动力学,减轻氧化应激反应,提升临床疗效.
Effect of Dihuang Drink combined with acupuncture on cognitive function,cerebral hemodynamics and oxidative stress of patients with cerebral infarction during convalescence
Objective To explore the effects of Dihuang Drink combined with acupuncture on cognitive dysfunction,hemodynamics,oxidative stress and serum matrix metalloproteinase-9(MMP-9),tissue inhibitor of metalloproteinase-1(TIMP-1)after cerebral infarction(CI).Methods Totally 128 CI patients admitted to our hospital from May 2021 to May 2022 were enrolled.They were randomly assigned into a control group(n=61,routine Western medicine[RWM]+acupuncture)and a treatment group(n=67,RWM+acupuncture+Dihuang Drink),After 3-month treatment,The curative effect was evaluated,the Mini Mental State Examination(MMSE)scores,Montreal Cognitive Assessment(MoCA)scores,hemodynamics(mean blood flow velocity[Vm],systolic blood flow velocity[Vs]and pulsatility index[PI]of intracranial artery),serological indicators(superoxide dismutase[SOD],glutathione peroxidase[GSH-Px],malondialdehyde[MDA],MMP-9,TIMP-1)were included as comparisons.The curative effect was assessed.Results The overall effective rate in the treatment group was significantly higher than that in the control group(95.52%[64/67]vs80.33%[49/61],P<0.05).After treatment,MMSE and MoCA scores in both groups were significantly increased(P<0.05),which increased notably in the treatment group compared with the control group(P<0.05).Significantly increased Vm and Vs,and significantly decreased PI were found in both groups than those before treatment(P<0.05),and the different was significant between groups for the above indexes(P<0.05).Significantly increased SOD and GSH-Px levels,and significantly decreased MDA levels were detected in both groups after treatment(all P<0.05),which were significantly pronounced in treatment group(all P<0.05).MMP-9 levels in both groups were significantly decreased(P<0.05),the decrease in the treatment group was more prevalent compared with the control group(P<0.05).TIMP-1 levels in both groups were significantly increased(P<0.05),the increase in the treatment group was more common than the control group(P<0.05).Conclusion Dihuang Drink combined with acupuncture can effectively improve cognitive dysfunction and cerebral hemodynamics,reduce oxidative stress response,and enhance clinical efficacy for CI patients.

Cerebral infarctionDihuang DrinkAcupunctureCognitive dysfunctionHemodynamicsOxidative stress

杨州、李泳学、林颖、徐乐乐、周姗、瞿晓东

展开 >

南京中医药大学连云港附属医院康复科,江苏 连云港 222004

脑梗死 地黄饮子 针刺 认知功能障碍 血流动力学 氧化应激

2024

河北中医
河北省医学情报研究所,河北省中医药学会

河北中医

CSTPCD
影响因子:0.951
ISSN:1002-2619
年,卷(期):2024.46(9)