Effect of acupoint application combined with modified Lichong Decoction on sequelae of pelvic inflammatory disease of Qi-deficiency and blood-stasis type
Objective To observe the effect of acupoint application combined with modified Lichong Decoction on sequelae of pelvic inflammatory disease(PID)of Qi-deficiency and blood-stasis type and its impacts on hemodynamic and immunological indexes.Methods Ninety-eight patients with sequelae of PID of Qi-deficiency and blood-stasis type were assigned in a 1∶1 ratio to modified Lichong Decoction(control group)or acupoint application plus modified Lichong Decoction(treatment group)by a random number table.The clinical efficacy,traditional Chinese medicine(TCM)symptom scores,pulsation index(PI)in uterine artery,end-diastolic velocity(EDV),resistance index(RI),the maximum depth diameter and the diameter of pelvic mass,intercellular adhesion molecule 1(ICAM-1),monocyte chemotactic protein-1(MCP-1),granulocyte-macrophage colony-stimulating factor(GM-CSF),CD4+,CD8+,and complement component C3 were compared.Results The total effective rate of the treatment group was significantly higher than that of the control group(97.96%[48/49]vs 83.67%[41/49],P<0.05).TCM symptom scores(lower abdominal pain or falling pain,aggravation of menstruation,apatheia,poor appetite,menstrual extension or menorrhagia,pale or lumpy menstrual blood,body fatigue,color white matter thin,more leucorrhea)in the both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).The maximum depth of pelvic effusion and the diameter of pelvic mass in the both groups were significantly decreased(P<0.05),which were significantly smaller in the treatment group than in the control group(P<0.05).Significantly decreased RI and PI levels,and increased EDV level were found in the both groups(all P<0.05),which were significantly pronounced in the treatment group(all P<0.05).The contents of ICAM-1,MCP-1 and GM-CSF in the both groups were significantly decreased(P<0.05),which in the treatment group were significantly lower than those in the control group(P<0.05).Significantly decreased CD8+levels,and increased CD4+and complement C3 levels were found in the both groups(all P<0.05),and the different was significant between groups for the above indexes(all P<0.05).Conclusion The combination of acupoint application and modified Lichong Decoction on sequelae of PID can improve the anti-inflammatory effect,improve their hemodynamics and immunological indexes,reduce pelvic effusion and mass.
万方数据
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