Effect of modified Yinchenhao Decoction assisted transarterial chemoembolization treatment on advanced primary liver cancer and its impacts for syndromes and JAK2-STAT3 signal pathway
Objective To explore the effects of modified Yinchenhao Decoction assisted transarterial chemoembolization(TACE)treatment on advanced primary liver cancer and its impacts for traditional Chinese medicine(TCM)syndromes and Janus kinase 2/signal transduction and transcriptional activator 3(JAK2-STAT3)signaling pathways.Methods A total of 107 patients with advanced primary liver cancer in Department of Oncology,Quanzhou Binhai Hospital from June 2020 to June 2022 were enrolled,and they were divided into control group(n=53)and study group(n=54)by a simple randomization method.All patients received TACE treatment,those in the study group additionally received modified Yinchenhao Decoction.A statistical analysis was conducted on efficacy,toxicity and side effects,TCM syndrome scores(hypochondrium pain,abdominal mass,abdominal distension),gene expression of JAK2-STAT3 signaling pathway and downstream target(B-cell lymphoma/leukemia-x long[Bcl-XL],Cyclin D1,cellular myelocytomatosis oncogene[c-Myc]),as well as liver function indicators(aspartate aminotrans-ferase[AST],total bilirubin[TBiL],alanine aminotransferase[ALT]).Results The disease control rate in the study group was significantly higher than that in the control group(79.63%[43/54]vs 58.49%[31/53],P<0.05).After treatment,the scores of hypochondriac pain,abdominal mass,abdominal distension,JAK2-STAT3 mRNA expression,protein expression of Bcl-XL,Cyclin D1,c-Myc signaling pathway,as well as the levels of AST,TBiL,ALT in the both groups were significantly lower than those before treatment(P<0.05),with significant differences between groups(P<0.05).The incidence of liver and kidney dysfunction(gradeⅠ-Ⅱ)was significantly lower in the study group than in the control group(P<0.05).Conclusion The modified Yinchenhao Decoction assisted TACE in patients with advanced primary liver cancer has a positive promoting effect on the improvement of TCM syndrome,liver function,and therapeutic effect by the downregulation of the protein expression of JAK2-STAT3 signaling pathway.
万方数据
维普
