Efficacy and safety of modified Banxia Xiexin Decoction combined with esomeprazole magnesium enteric-coated tablets in treating non-erosive gastroesophageal reflux disease of liver and stomach heat syndrome
Objective To analyze the efficacy and safety of modified Banxia Xiexin Decoction combined with esomeprazole magnesium enteric-coated tablets in treating non-erosive gastroesophageal reflux disease(NERD)of liver and stomach heat syndrome.Methods A total of 98 patients with NERD of liver and stomach heat syndrome divided into the control group(n=49)and the study group(n=49)according to a random number table.All patients were given esomeprazole magnesium enteric-coated tablets,and those in the study group were additionally given modified Banxia Xiexin Decoction.After 8-week of treatment,the total scores of traditional Chinese medicine(TCM)syndromes,esophageal motility(lower esophageal sphincter pressure[LESP],upper esophageal sphincter pressure[UESP]),gastrointestinal hormones(motilin,gastrin,ghrelin,vasoactive intestinal peptide[VIP])and 17-item Hamilton Rating Scale for Depression(HAMD-17),and treatment-emergent adverse events(TEAEs)between the two groups before and after treatment were compared.Results The total effective rate of the study group was significantly higher than that of the control group(95.92%[47/49]vs 73.47%[36/49],P<0.05).After treatment,the scores TCM syndrome and HAMD-17 of the two groups were significantly lower than those before treatment(P<0.05),and the study group was significantly lower than the control group(P<0.05).After treatment,significantly increased LESP and decreased UESP in both groups were found(both P<0.05),and with significant difference between groups(both P<0.05).After treatment,significantly higher the levels of motilin,gastrin and ghrelin and lower VIP level were detected in the two groups(all P<0.05),and the improvements were more pronounced in the study group relative to the control group(P<0.05).No TEAEs was found in both groups.Conclusion The modified Banxia Xiexin Decoction combined with esomeprazole magnesium enteric-coated tablets has a definite therapeutic effect on NERD of liver and stomach heat syndrome,it can improve esophageal motility,depression,regulate motilin,gastrin,ghrelin,VIP,and it has a high safety.
Gastroesophageal refluxIntegrated traditional Chinese and Western medicine therapy
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维普
