首页|老年非酒精性脂肪肝的中医体质辨识及相关因素预测价值研究

老年非酒精性脂肪肝的中医体质辨识及相关因素预测价值研究

Predictive value of traditional Chinese medicine constitution identification and risk factors for senile nonalcoholic fatty liver disease

扫码查看
原文链接
  • 维普
  • 万方数据
目的 探讨非酒精性脂肪肝(NAFLD)的中医体质及NAFLD相关危险因素预测价值.方法 以 835 例60～91岁参检者为研究对象,采用横断面调查方法,所有参检者进行数据收集,包括年龄、性别、既往史、身高、体质量、腰围、血压、生化指标、B超检查等,并对参检者进行中医体质辨识,根据B超结果将参检者分为对照组和NAFLD组,进行相关数据分析.结果 NAFLD组痰湿质高于对照组[72 例(19.46%)vs 39 例(8.39%)](P<0.001),湿热质显著高于对照组[20 例(5.41%)vs 11 例(2.37%)](P<0.05).痰湿质、湿热质、腰围、空腹血糖(FPG)、血红蛋白(Hb)、尿酸(UA)、γ-谷氨酰基转移酶(GGT)、丙氨酸氨基转移酶(ALT)、甘油三酯(TG)、糖化血红蛋白(HbA1c)、体质量指数(BMI)、舒张压(DBP)、收缩压(SBP)会对NAFLD产生显著的正向影响(P<0.05),各项回归系数分别为:0.970、0.858、0.097、0.274、0.033、0.003、0.016、0.057、0.976、0.545、0.333、0.033、0.008.痰湿质、湿热质、阳虚质、年龄、GGT、ALT、高密度脂蛋白胆固醇(HDL-C)、Hb、TG、BMI、UA、HbA1c、FPG、腰围、DBP、SBP预测NAFLD的受试者工作特征(ROC)曲线下面积(AUC)分别为:0.556、0.515、0.456、0.397、0.647、0.667、0.356、0.629、0.693、0.749、0.577、0.664、0.636、0.730、0.612.腰围、BMI均对NAFLD有较好的预测价值.结论 NAFLD组痰湿质、湿热质高于对照组,湿热质、痰湿质、腰围、FPG、Hb、UA、GGT、ALT、TG、HbA1c、BMI、DBP、SBP会对NAFLD产生显著的正向影响,腰围、BMI均对NAFLD有较好的预测价值.
Objective To investigate the predictive value of traditional Chinese medicine(TCM)constitution identification and risk factors for senile nonalcoholic fatty liver disease(NAFLD).Methods This was a cross-sectional survey involving 835 participants aged 60 to 91 years old.The data of all the participants,including age,gender,past history,height,weight,waist circumference(WC),blood pressure,biochemical indicators,B-ultrasound examination were collected.An analysis of TCM constitution identification was conducted,and the participants were divided into control group and NAFLD group according to the results of B-ultrasound,and the relevant data was analyzed.Results The participants with phlegm dampness(19.46%[72/370]vs 8.39%[39/465],P<0.001)and damp-heat constitution(5.41%[20/370]vs 2.37%[11/465],P<0.05)in the NAFLD group were significantly higher than those in the control group.Phlegm-dampness constitution,damp-heat constitution,WC,fasting blood glucose(FPG),hemoglobin(Hb),uric acid(UA),gamma-glutamyltransferase(GGT),alanine aminotransferase(ALT),triglyceride(TG),glycated hemoglobin(HbA1c),body mass index(BMI),diastolic blood pressure(DBP),systolic blood pressure(SBP)had a significant positive effect on NAFLD(P<0.05),and the regression coefficients were 0.970,0.858,0.097,0.274,0.033,0.003,0.016,0.057,0.976,0.545,0.333,0.033,0.008,respectively.The area under the receiver operating characteristic(ROC)curve(AUC)for predicting NAFLD by phlegm-dampness constitution,damp-heat constitution,yang-deficiency constitution,age,GGT,ALT,high-density lipoprotein cholesterol(HDL-C),Hb,TG,BMI,UA,HbA1c,FPG,WC,DBP and SBP were:0.556,0.515,0.456,0.397,0.647,0.667,0.356,0.629,0.693,0.749,0.577,0.664,0.636,0.730,0.612.Both WC and BMI had better predictive values for NAFLD.Conclusion The NAFLD patients present significantly higher phlegm-dampness constitution and damp-heat constitution relative to the controls.Phlegm-dampness constitution,damp-heat constitution,WC,FPG,Hb,UA,GGT,ALT,TG,HbA1c,BMI,DBP and SBP have significant positive effects on NAFLD.Both WC and BMI have better predictive values for NAFLD.

Fatty liverTraditional Chinese medicine constitution identification

王露、刘红军、聂颖、迟文、白雪、马丽华、薛丽佳

展开 >

北京交通大学社区卫生服务中心,北京 100044

脂肪肝 中医体质类型

2024年北京市海淀区卫生健康发展科研培育计划

HP2024-02-701001

2024

10.3969/j.issn.1002-2619.2024.09.013

河北中医
河北省医学情报研究所,河北省中医药学会

河北中医

CSTPCD
影响因子：0.951
ISSN：1002-2619
年,卷(期)：2024.46(9)