Clinical research of modified Duhuo Jisheng Decoction combined with sodium hyaluronate in the treatment of knee osteoarthritis with liver and kidney deficiency
Objective To observe the safety and clinical efficacy of modified Duhuo Jisheng Decoction plus intra-articular injection of sodium hyaluronate in the treatment of knee osteoarthritis(KOA)with liver and kidney deficiency.Methods A total of 108 patients with KOA of liver and kidney deficiency who met the research criteria were selected.They were assigned in a 1∶1∶1 to intra-articular injection of sodium hyaluronate(sodium hyaluronate group),modified Duhuo Jisheng Decoction(traditional Chinese medicine[TCM]group)or modified Duhuo Jisheng Decoction plus sodium hyaluronate(combined group)using a random number table for 8 weeks.The Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),osteoarthritis index score,TCM syndrome score,tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),alanine aminotransferase(ALT)and serum creatinine(SCr)levels were assessed among the three groups before and after treatment.Results A total of 104 subjects participated in the complete research process,including 36 cases of the sodium hyaluronate group,33 cases of the TCM group,and 35 cases of the combined group.After treatment,the scores of WOMAC,osteoarthritis index and TCM syndrome of the three groups were significantly lower than those before treatment(P<0.05),which were significantly lower in the combined group than in the sodium hyaluronate group and the TCM group(P<0.05).After treatment,TNF-α and IL-1 in the three groups were significantly lower than those before treatment(P<0.05),which in the combined group were significantly lower than those in the sodium hyaluronate group and the TCM group(P<0.05).There was no significant difference in ALT and Cr between the three groups before and after treatment(P>0.05).Conclusion The combination of modified Duhuo Jisheng Decoction and intra-articular injection of sodium hyaluronate is superior to the simple use one of them for KOA,it can control symptoms,improve joint function,control inflammatory response,and with safe and reliable.
Osteoarthritis,KneeLiver and kidney deficiencyDuhuo Jisheng Decoction
万方数据
维普
