Correlation study between different traditional Chinese medicine syndromes and liver pathology in primary biliary cholangitis
Objective To explore the correlation between different traditional Chinese medicine(TCM)syndromes and liver pathology in patients with primary biliary cholangitis(PBC).Methods Totally 88 patients with PBC were included based on different TCM syndrome,laboratory examination and liver biopsies.Its comorbidities were counted.The inflammation score and liver fibrosis stage in PBC patients were routinely determined.Results The TCM syndrome distribution in PBC patients from high to low was as follows:liver-kidney yin deficiency syndrome,liver spleen deficiency,damp-heat accumulation syndrome,blood stasis syndrome.The response to ursodeoxycholic acid(UDCA)in PBC patients with liver spleen deficiency and damp-heat accumulation syndrome was significantly higher than that in PBC patients with blood stasis syndrome(P<0.05).The incidence of hepatocirrhosis in PBC patients with liver-kidney yin deficiency syndrome and blood stasis syndrome was significantly higher than that in PBC patients with liver spleen deficiency(P<0.05).The levels of alkaline phosphatase(ALP),total bilirubin(TBiL),direct bilirubin(DBil),total bile acids(TBA)in PBC patients with blood stasis syndrome were significantly higher than those in PBC patients with liver spleen deficiency(P<0.05).The level of TBA in PBC patients with liver-kidney Yin deficiency syndrome was significantly higher than that in PBC patients with liver spleen deficiency(P<0.05).The level of total cholesterol(TC)in PBC patients with damp-heat accumulation syndrome was significantly higher than that in PBC patients with liver spleen deficiency(P<0.05).There was a statistically significant difference in the incidence of hyperlipidemia and Sjogren syndrome(SS)among the PBC patients with four different TCM syndrome types(P<0.05).The incidence of hyperlipidemia in PBC patients with damp-heat accumulation syndrome was significantly higher than that in PBC patients with liver spleen deficiency(P<0.05).The incidence of SS in PBC patients with liver-kidney yin deficiency syndrome was significantly higher than that in PBC patients with damp-heat accumulation syndrome(P<0.05).There were statistically significant differences in the liver inflammation and fibrosis grading among PBC patients with four different TCM syndrome types(P<0.01).The fibrosis grading in PBC patients with liver-kidney yin deficiency syndrome and blood stasis syndrome was significantly higher than that in PBC patients with liver spleen deficiency(P<0.01).Conclusion The syndromes of liver-kidney yin deficiency and blood stasis may be related to the degree of liver fibrosis.
万方数据
维普
