目的 观察亚甲方联合平瘿散对亚急性甲状腺炎患者的治疗效果,及对患者血清过氧化物酶抗体(TPO-Ab)、转化生长因子β1(TGF-β1)和甲状腺球蛋白抗体(TgAb)的影响.方法 将102例SAT患者按照随机数字表法分为2组,对照组51例予常规西药治疗,治疗组51例予亚甲方口服联合平瘿外敷治疗,治疗4周后评估2组临床疗效.比较2组治疗前后中医症状评分及血清TPO-Ab、TGF-β1、TgAb、促甲状腺激素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)水平和131I甲状腺摄取率变化.结果 治疗组总有效率98.04％(50/51),对照组总有效率98.04％(50/51),2组临床疗效比较差异无统计学意义(P＞0.05).与本组治疗前相比,治疗后2组甲状腺痛、发热、咽痛、心悸、乏力、烦躁、消瘦评分均下降(P＜0.05),且治疗后治疗组甲状腺痛、咽痛、心悸、乏力、烦躁、消瘦评分均低于对照组(P＜0.05).与本组治疗前相比,治疗后2组TPO-Ab、TGF-β1、TgAb水平均下降(P＜0.05),且治疗后治疗组TGF-β1水平低于对照组(P＜0.05).与本组治疗前相比,治疗后2组血清FT3、FT4水平均显著降低(P＜0.05),TSH水平显著升高(P＜0.05),且治疗后治疗组血清FT3、FT4水平低于对照组(P＜0.05).与本组治疗前相比,治疗后2组2 h、6 h、24 h 131I甲状腺摄取率均升高(P＜0.05),且治疗后治疗组2 h、6 h、24 h 131I摄入率均高于对照组同期(P＜0.05).结论 亚甲方联合平瘿散治疗SAT,能改善患者甲状腺功能和症状,降低TGF-β1水平.
Effect of Yajia Formula combined with Pingying Powder for thyroid peroxidase antibody,transforming growth factor-beta1 and thyroglobulin antibody in patients with subacute thyroiditis
Objective To analyze the therapeutic effect of Yajia Formula combined with Pingying Powder for patients with subacute thyroiditis(SAT),and its influence on thyroid peroxidase antibody(TPO-Ab),transforming growth factor-beta1(TGF-β1)and thyroglobulin antibody(TgAb).Methods Totally 102 SAT patients were randomised 1∶1 to receive routine Western medicine(RWM)(control group)or oral Yajia Formula+external application with Pingying Powder(treatment group).Treated for 4 weeks,the aim was to compare traditional Chinese medicine(TCM)syndrome score,serum TPO-Ab,TGF-β1,TgAb,thyroid stimulating hormone(TSH),free thyroxine(FT4),free triiodothyronine(FT3),thyroid 131I uptake measurements.The curative effect was assessed.Results The overall effective rate in the treatment group was comparable to the control group(98.04％[50/51]vs 98.04％[50/51],P＞0.05).After treatment,TCM symptom(thyroid pain,fever,sore throat,palpitations,fatigue,irritability,weight loss)scores in groups were significantly decreased(P＜0.05),TCM symptom(thyroid pain,sore throat,palpitations,fatigue,irritability,weight loss)scores decreased notably in the treatment group compared with the control group(P＜0.05).TPO-Ab,TGF-β1,TgAb levels in groups were significantly decreased(P＜0.05),TGF-β,was significantly lower in the treatment group than in the control group(P＜0.05).After treatment,significantly decreased FT3 and FT4,and increased TSH were found in the two groups(all P＜0.05).FT3 and FT4 were significantly lower in the treatment group than in the control group(P＜0.05).After treatment,2 h,6 h,24 h thyroid 131I intake rate in groups increased significantly(P＜0.05),the increase in the treatment group was more common than the control group(P＜0.05).Conclusion Yajia Formula combined with Pingying Powder for SAT patients can improve patients'thyroid function and symptoms,and reduce TGF-β1 levels.
ThyroiditisSubacuteIntegrated traditional Chinese and Western medicine therapy
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