Effect of repetitive transcranial magnetic stimulation combined with mindfulness decompression therapy and acupuncture on negative emotion and cognitive function in patients with generalized anxiety disorder
Objective To explore the effect of repetitive transcranial magnetic stimulation(rTMS)combined with mindfulness decompression therapy and acupuncture on negative emotion and cognitive function in patients with generalized anxiety disorder(GAD).Methods Eighty GAD patients were randomly assigned into treatment group(n=42)and control group(n=38).All patients were managed by mindfulness decompression therapy combined with acupuncture,and those in treatment group were additionally treated with rTMS.Treated for 6 weeks,the aim was to compare malondialdehyde(MDA),superoxide dismutase(SOD),traditional Chinese medicine(TCM)symptom score,Pittsburgh Sleep Quality Index(PSQI),Hamilton Depression Rating Scale-17(HAMD-17),Hamilton Anxiety Scale(HAMA),Montreal Cognitive Assessment(MoCA)scores on day 0,and at weeks 1,2 and 6 of treatment.The curative effect was assessed.Results At weeks 1,2 and 6 of treatment,TCM symptom(dysphoria and irritable,bitter taste and mouth dryness)scores,PSQI,HAMD-17,HAMA scores in groups were significantly decreased(P＜0.05),which were significantly lower in the treatment group than in the control group(P＜0.05).MoCA scores in groups at weeks 1,2 and 6 were significantly increased(P＜0.05),which were significantly increased in the treatment group relevant to the control group(P＜0.05).At weeks 1,2 and 6 of treatment,significantly decreased MDA level and increased SOD level were found in groups(all P＜0.05),and the treatment group was superior to the control group for MDA and SOD levels(all P＜0.05).The overall effective rate in the treatment group was significantly higher than that in the control group(92.86％[39/42]vs 71.05％[27/38],P＜0.05).Conclusion The rTMS combined with mindfulness decompression therapy and acupuncture can improve negative emotion and cognitive function,inhibit the body's oxidative stress response,and improve sleep quality in GAD patients.
Transcranial magnetic stimulationGeneralized anxiety disorderMindfulnessNegative emotionCognitive dysfunction
万方数据
维普
