Clinical efficacy of herbal fumigation combined with aerobic exercise for rheumatoid arthritis
Objective To observe the clinical efficacy of herbal fumigation combined with aerobic exercise for rheumatoid arthritis(RA).Methods A total of 96 RA patients treated in Department of Integrated Traditional Chinese Medicine,the First Affiliated Hospital of Xinjiang Medical University from March 2022 to April 2023 were randomly assigned into treatment group(n=48)and control group(n=48).All patients were managed by methotrexate,and those in treatment group were additionally treated with herbal fumigation combined with aerobic exercise.Treated for 4 weeks,the aim was to compare Disease Activity Score in 28 joints-Erythrocyte Sedimentation Rate(DAS28-ESR)on day 0,and at weeks 1,2,4,C-reactive protein(CRP),rheumatoid factor(RF),interleukin 17(IL-17),T helper 17(Th17)cells,regulatory t cells(Treg),Th17/Treg,patient-reported outcomes(PRO)in patients with RA.Results At weeks 1,2 and 4,DAS28-ESR scores in the two groups were significantly decreased than before treatment(P＜0.05),the decrease in the treatment group was more prevalent than the control group(P＜0.05).After treatment,the levels of RF,ESR,CRP,IL-17 in the two groups were significantly decreased(P＜0.05),which were significantly lower in the treatment group than in the control group(P＜0.05).After treatment,significantly decreased Th17/Treg and Th17,and increased Treg were found in the two groups(all P＜0.05),and the treatment group was superior to the control group for Th17/Treg,Th17,Treg(all P＜0.05).The dimension score of PRO in the two groups was significantly increased(P＜0.05),the increase in the treatment group was more common than the control group(P＜0.05).The overall effective rate in the treatment group was significantly higher than that in the control group(87.50％[42/48]vs 60.42％[29/48],P＜0.05).Conclusion For RA patients,herbal fumigation combined with aerobic exercise can effectively relieve clinical symptoms,inhibit inflammation and improve quality of life.
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