Effect of Shenqi Yizhu Decoction combined with chemotherapy on survival time and quality of life of patients with advanced gastric cancer
Objective To analyze the effect of Shenqi Yizhu Decoction with chemotherapy on survival time and quality of life of patients with advanced gastric cancer(AGC).Methods A total of 92 AGC patients treated in Department of Oncology,Tianchang Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were randomly assigned into treatment group(n=46)and control group(n=46).All patients were managed by XELOX regimen(capecitabine plus oxaliplatin),and those in treatment group were additionally treated with Shenqi Yizhu Decoction.The treatment continued for 4 courses(1 course for 3 weeks),the aim was to compare traditional Chinese medicine(TCM)syndrome score,tumor markers including carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA),CA1 99,immune function,the European Organisation for research and treatment of cancer quality of life questionnaire core 30(EORTC QLQ-C30)scores,as well as treatment-emergent adverse events(TEAEs).The median survival time(MST)and time to tumor progression(TTP)were assessed during 2-year follow-up study.Results The disease control rate in the treatment group was significantly higher than that in the control group(86.96％[40/46]vs 67.39％[31/46],P＜0.05).After treatment,TCM syndrome(epigastric pain,reduced food intake and poor appetite,nausea and vomiting,tiredness)scores,CA125,CA199 and CEA levels in the both groups were decreased(P＜0.05),which were significantly decreased in the treatment group relevant to the control group(P＜0.05).After treatment,significantly increased CD3+,CD4+and CD4+/CD8+levels,and decreased CD8+level were found in the both groups(all P＜0.05),and the treatment group was superior to the control group for the levels of CD3+,CD4+,CD4+/CD8+,CD8+(all P＜0.05).The EORTC QLQ-C30 scores in the both groups were significantly increased(P＜0.05),the increase in the treatment group was more common than the control group(P＜0.05).The TEAEs in the treatment group was significantly lower than that in the control group(28.26％[13/46]vs 65.22％[30/46],P＜0.05).The TTP and MST in the treatment group were significantly longer than those of the control group(P＜0.05).Conclusion Compared to chemotherapy alone,the combination of Shenqi Yizhu Decoction with chemotherapy has better efficacy in treating AGC patients,which can reduce adverse reactions,improve immune function,prolong survival time,and improve quality of life.
Gastric cancerChemotherapyPhytotherapyProgression-free survivalQuality of life
万方数据
维普
