Effect of Kaiqiao Xingshen Buxu Tongluo acupuncture combined with repetitive transcranial magnetic stimulation on limb motor function in patients with post-stroke hemiplegia
Objective To explore the effect of Kaiqiao Xingshen Buxu Tongluo acupuncture combined with repetitive transcranial magnetic stimulation(rTMS)on limb motor function in patients with post-stroke hemiplegia.Methods Ninety-eight patients with post-stroke hemiplegia were recruited in this study,and they were assigned in a 1∶1 ratio to rTMS(control group)or Kaiqiao Xingshen Buxu Tongluo acupuncture plus rTMS(treatment group)by a random number table for 3 months.The clinical efficacy,traditional Chinese medicine(TCM)symptom scores,cerebral hemodynamics,brain injury markers,limb motor function scores,and treatment-emergent adverse events(TEAEs)were evaluated between two groups.Results After treatment,the TCM syndrome scores(incomplete use,angular deviation,limb weakness,and pale complexion)of the both groups were significantly lower than those before treatment(P＜0.05),and which were significantly lower in the treatment group than in the control group(P＜0.05).After treatment,the blood flow velocity of the middle cerebral artery,basilar artery and vertebral artery in both groups were significantly faster than those before treatment(P＜0.05),and which were significantly faster in the treatment group than in the control group(P＜0.05).After treatment,the levels of brain fatty acid binding protein(B-FABP),neuron specific enolase(NSE)and mannose-binding lectin-associated serine protease 3(MASP-3)in the both groups were significantly lower than those before treatment(P＜0.05),which in the treatment group were significantly lower than those in the control group(P＜0.05).After treatment,the scores of Fugl Meyer Motor Function Scale(FMA),Berg Balance Scale(BSS),and 6-minute walking distance(6MWD)in the both groups were significantly higher than those before treatment(P＜0.05),the increases were more common in the treatment group relative to the control group(P＜0.05).The total effective rate of the treatment group was significantly higher than that of the control group(91.84％[45/49]vs 73.47％[36/49],P＜0.05).The incidence of TEAEs in the treatment group and the control group was comparable(12.24％[6/49]vs 8.16％[4/49],P＞0.05).Conclusion The combination of Kaiqiao Xingshen Buxu Tongluo acupuncture and rTMS has a significant effect in the treatment of post-stroke hemiplegia,which can improve patients'TCM syndromes,improve cerebral hemodynamics,reduce the level of brain injury markers,and im-prove patients'limb motor function,it has a good safety.
HemiplegiaStrokeAcupuncture therapyRepetitive transcranial magnetic stimulation
万方数据
维普
