Clinical efficacy of Qingjie Mixture combined with ganciclovir in treatment of children with infectious mononucleosis(blazing heat-toxin type)caused by Epstein-Barr virus infection and its influence on immune function
Objective To observe the efficacy of Qingjie Mixture combined with ganciclovir in treatment of children with infectious mononucleosis(IM)(blazing heat-toxin type)caused by Epstein-Barr virus(EBV)infection.Methods Eighty cases of EBV-infected IM(blazing heat-toxin type)children were randomly divided into control group and research group,40 cases in each group.Control group was treated with ganciclovir,and research group was treated with Qingjie Mixture on the basis of control group.The clinical efficacy,symptoms and signs score,EBV deoxyribonucleic acid(EBV-DNA)level,liver function,T lymphocyte subsets(CD4+,CD4+/CD8+,CD8+,atypical lymphocyte ratio),serum inflammatory indicators and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of research group was significantly higher than that in control group(P＜0.05);the scores of fever,angina,superficial lymphadenopathy,hepatomegaly,splenomegaly in both groups were lower than those before treatment,and were lower in research group than those in control group(P＜0.05);the EBV-DNA levels,scores of aspartate aminotransferase and alanine aminotransferase in both groups were lower than those before treatment,and were lower in research group than those in control group(P＜0.05);the percentages of CD4+and CD4-/CD8+in both groups were higher than those before treatment,and were higher in research group than those in control group,while the percentages of CD8+and atypical lymphocytes were lower than those before treatment,and were lower in research group than those in control group(P＜0.05);the levels of interleukin-4(IL-4),interferon-γ(IFN-γ),granzyme B and perforin in both groups were lower than those before treatment,and were lower in research group than those in control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Qingjie Mixture combined with ganciclovir can significantly improve the immunologic function in children with IM(blazing heat-toxin type)caused by EBV infection,with excellent clinical therapeutic effect and safety.
EBVInfectious mononucleosis(heat-toxic type)Qingjie MixtureGanciclovirChildrenImmune function
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