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基于古今医案云平台分析中医药治疗抑郁症伴失眠的用药规律

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目的 分析挖掘中医药治疗抑郁症伴失眠的用药规律,为临床治疗抑郁症伴失眠提供用药参考.方法 通过检索知网、万方、维普、CBM数据库中抑郁症伴失眠现代文献的有效验案,经数据筛选、数据清洗、数据标准化处理等处理,建立标准化医案数据库,利用古今医案云平台进行频次统计、关联分析、复杂网络、聚类分析等数据分析法,分析中医药治疗抑郁症伴失眠的用药频次、四气、五味、归经、核心处方等用药规律.结果 共得到处方87首,药物193味,高频药物共15味,主要有柴胡、甘草、酸枣仁、半夏、白芍、当归、茯苓等,常用药物组合包括"白芍-柴胡""当归-柴胡""黄芩-柴胡"等.药性以平、温为主;药味以甘、苦、辛多见;归心、肝、脾、肺经最多.聚类分析将高频药物分为5组,涉及疏肝理气;燥湿化痰,健脾和胃;和解少阳,安神定志;宁心安神等剂.结论 通过数据挖掘方法,总结出中医药治疗抑郁症伴失眠注重疏肝解郁,养心安神,兼顾调和阴阳气血,对临床上抑郁症伴失眠的治疗具有参考价值.
Analyzing the medication rule of TCM in treating depression with insomnia based on the Ancient and Modern Medical Case Cloud Platform
Objective To analyze and explore the drug law of TCM in treating depression with insomnia,and provide reference for clinical treatment of depression with insomnia.Methods Search effective verification of modern literature on depression with insomnia through CNK1,Wanfang,VIP,CBM databases.Establishing database of standardized basis by data selection,data cleaning,data standardization processing.Using Ancient and Modern Medical Case Cloud Platform for frequency statistics,correlation analysis,complex networks,data analysis methods,such as cluster analysis to analysis use frequency,four characters(FC),five tastes(FT)and channel distributions of herbs,core prescription medication regularly.Results A total of 87 prescriptions were obtained,including 193 drugs and 15 high frequency drugs,mainly including Bupleurum root,Licorice root,Jujube seed,Pinellia root,Angelica root,Poria root,etc.Commonly used drug combinations included"Pinellia root-Bupleurum root","Angelica root-Bupleurum root","Scutellaria root-Bupleurum root".The medicinal properties are mainly flat and warm;medicine tastes are mainly sweet,bitter,and pungent;the meridians of heart,liver,spleen and lung are mostly used.The high frequency drugs were divided into 5 groups by cluster analysis,which involved soothing the liver and regulating qi;drying dampness and resolving phlegm,invigorating the spleen and stomach;reconciliation Shaoyang,peacing heart and tranquilizing mind.Conclusion Through the method of data mining,it is concluded that TCM treatment of depression with insomnia pays attention to relieving liver depression,nourishing heart and mind,and reconciling yin,yang,qi and blood,which has reference value for clinical treatment of depression with insomnia.

Depression with insomniaThe law of drug useData miningAncient and Modern Medical Case Cloud Platform

周童、许鹏、孙易娜、章程鹏

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湖北中医药大学中医临床学院,湖北武汉 430061

抑郁症伴失眠 用药规律 数据挖掘 古今医案云平台

国家自然科学基金

81503629

2024

湖北中医药大学学报
湖北中医药大学

湖北中医药大学学报

CSTPCD
影响因子:0.873
ISSN:1008-987X
年,卷(期):2024.26(1)
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