Application value of Shidachuan Mixture combined with chemotherapy and its effects on KPS behavioral ability in patients with middle and advanced esopha-geal squamous cell carcinoma
Objective To observe the application value of Shidachuan Mixture combined with chemotherapy and its effects on KPS behavioral ability in patients with middle and advanced esophageal squamous cell carcinoma(ESCC).Methods A total of 120 patients with middle and advanced ESCC were randomly divided into study group and control group,60 cases in each group.Control group was treated with routine chemotherapy(paclitaxel+cisplatin),while study group was additionally treated with Shidachuan Mixture.The clinical curative effect after treatment,changes in levels of tumor markers squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA),cytokeratin-19 soluble fragment(CYFRA21-1),and infla-mmatory factors interleukin-2(IL-2),tumor necrosis factor-α(TNF-α),transforming growth factor-β(TGF-β),TCM syndrome scores,Karnofsky Performance Assessment Scale(KPS)scores,Quality of Life Scale for tumor patients(QoL)scores,and the incidence of adverse reactions were compared between the two groups.Results After treatment,the total response rate of treatment and clinical control rate in study group were significantly higher than those in control group(P＜0.05);SCC-Ag,CEA,CYFRA21-1,IL-2,TNF-α and TGF-β levels in both groups were decreased,which were lower in study group than control group(P＜0.05);TCM symptom scores in both groups were decreased,which were lower in study group than control group(P＜0.05),KPS and QoL scores were increased,which were higher in study group than control group(P＜0.05);the incidence of adverse reactions in study group was lower than that in control group(P＜0.05).Conclusion The curative effect of Shidachuan Mixture combined with chemotherapy is significant in patients with middle and advanced ESCC,which can effectively reduce levels of tumor markers and inflammatory factors,relieve TCM symptoms,improve behavioral ability and quality of life,and reduce the occurrence of adverse reactions.
Esophageal squamous cell carcinomaMiddle and advanced stageShidachuan MixtureChemotherapyPaclitaxelCisplatinBehavioral ability
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