Experimantal progress of acupuncture to regulate the intervention of mitophagy pathways in aging-associated cognitive decline
Aging-associated cognitive decline(AACD)refers to a class of diseases with cognitive dysfunction as the main clinical manifestations caused by aging,including Alzheimer's disease,Parkinson's disease,cerebral hemorrhage,cerebral ischemia/reperfusion,depression,etc.Acupuncture and moxibustion has a unique effect on the AACD diseases.Studies have found that acupuncture and moxibustion can prevent and treat AACD,and the mechanism may be related to the regulation of mitochondrial autophagy.In this paper,the relevant experimental studies on the prevention and treatment of AACD by acupuncture and moxibustion through the regulation of mitochondrial autophagy in the past five years were summarized,and the regulatory effects of acupuncture and moxibustion on ubiquitin-mediated,receptor protein-mediated,lipid-mediated and synthetically mediated mitochondrial autophagy were reviewed,in order to provide certain theoretical reference for the treatment of AACD and further research.
NETL
NSTL
万方数据
