Therapeutic effect study on Erxian Decoction combined with sertraline in treat-ment of elderly patients with tumor related depression
Objective To observe the therapeutic effect of modified Erxian Decoction combined with sertraline in treatment of elderly patients with tumor related depression(ETRD).Methods 60 patients with ETRD were randomly divided into treatment group and control group,with 30 cases in each group.Control group received sertraline,while treatment group received modified Erxian Decoction on the basis of control group.The efficacy of two groups of Hamilton Depression Rating Scale(HAMD),Depression Screening Scale(PHQ-9),HAMD,Pittsburgh Sleep Quality Index(PSQI)scores,four dimensions of Quality of Life Questionnaire(QLQC30),serotonin(5-HT),norepinephrine(NE),interleukin-6(IL-6)levels,CD3+,CD4+,and CD8+T lymphocyte subsets percentage were compared.Results After treatment,the total effective rate of HMAD in treatment group was significantly higher than that in control group(P＜0.05);the PHQ-9,HAMD,and PSQI scores of both groups were lower than those before treatment,and were lower in treatment group than control group(P＜0.05);four dimensions scores in both groups of QLQC30 were higher than before treatment,and were higher in treatment group than control group(P＜0.05);5-HT and NE levels in both groups were higher than before treatment,and were higher in treatment group than control group,while IL-6 levels were lower in both groups than before treatment,and were lower in observation group than control group(P＜0.05);the percentage of CD3+and CD4+in both groups were higher than before treatment,and was higher in treatment group than control group,while CD8+percentage was lower in both groups than before treatment,and was lower in observation group than control group(P＜0.05).Conclusion Modified Erxian Decoction combined with sertraline can significantly reduce depressive symptoms in ETRD patients,improve sleep and quality of life,increase the levels of monoamine neurotransmitters factors,decrease inflammatory factors,and enhance patients'immunity.
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