Curative effect of Danshen Injection combined with candesartan cilexetil tablet and its influences on cardiac function indexes,hemorheology,and serum indexes in the elderly with chronic heart failure
Objective To observe the curative effect of Danshen Injection combined with candesartan cilexetil tablet and its influences on cardiac function indexes,hemorheology,serum indexes in the elderly with chronic heart failure(CHF).Methods A total of 84 elderly patients with CHF were randomly divided into Western medicine group and Chinese-Western combination group,with 42 cases each.Western medicine group received candesartan cilexetil tablets,while Chinese-western combination group received Danshen Injection on the basis of western medicine group.The total response rate of treatment,cardiac function indexes[left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV),left ventricular ejection fraction(LVEF)],hemorheology[hematokrit(HCT),D-dimer(D-D),fibrinogen(FIB)],serum indexes[N-terminal pro brain natriuretic peptide(NT-proBNP),homocysteine(Hcy)]and adverse reactions in the two groups were compared.Results After treatment,total response rate of treatment was higher in Chinese-Western combination group than Western medicine group(P＜0.05);Hcy,LVESV,LVEDV,HCT,D-D,FIB,and NT-proBNP were decreased in both groups,which were lower in Chinese-Western combination group(P＜0.05),while LVEF was increased,which was higher in Chinese-Western combination group(P＜0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P＞0.05).Conclusion Danshen Injection combined with candesartan cilexetil tablet has good curative effect in elderly patients with CHF,which can protect cardiac function,improve hemorheology indexes,reduce NT-proBNP and Hcy levels with good safety.
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