Effect of Jiedu Xiaoyong Zhitong Prescription combined with methylpredniso-lone sodium succinate on the change of average platelet volume in peripheral blood of children with abdominal IgA vasculitis
Objective To observe the effect of Jiedu Xiaoyong Zhitong Prescription combined with methylprednisolone sodium succinate on the changes of peripheral platelet volume(MPV)in children with abdominal IgA vasculitis.Methods A total of 60 children with abdominal IgA vasculitis were randomly divided into study group and control group,with 30 cases in each group.Control group was treated with methylprednisolone sodium succinate,and study group was treated with Jiedu Xiaoyong Zhitong Prescription on the basis of control group.The efficacy of the two groups was compared,including the relief of abdominal pain,the conversion of fecal occult blood to negative,the time of rash disappearance,the main and secondary symptoms of TCM syndrome,and the scores of immunoglobulin G(IgG),IgM,interleukin-6(IL-6),IL-8,T lymphocytes CD4+,CD8+,CD4+/CD8+,immunoglobulin A(IgA),complement C3,mean platelet volume(MPV)and platelet count(PLT)before and after treatment.Results After treatment,the total effective rate of study group was higher than that of control group(P＜0.05);compared with control group,the reduction time of abdominal pain,fecal occult blood turned negative,and rash disappearance in study group were shorter(P＜0.05);the contents of IgG,CD4+,CD4+/CD8+,complement C3 and MPV in both groups were higher than those before treatment,while the main and secondary symptoms of TCM syndrome,the points of IgM,IL-6,IL-8,CD8+,IgA and PLT were lower(P＜0.05),and the indexes above were all superior in study group to those in control group(P＜0.05).Conclusion Jiedu Xiaoyong Zhitong Prescription combined with methylprednisolone has excellent efficacy in treatment of children with abdominal IgA vasculitis,which can reduce the TCM syndrome score,promote the normalization of humoral immunity and cellular immunity,regulate the levels of IL-6 and IL-8,increase the level of complement C3,and regulate platelet parameters.
IgA vasculitisVentral typePediatricsJiedu Xiaoyong Zhitong PrescriptionMethylprednisoloneMean platelet volume
NETL
NSTL
万方数据
