Efficacy of Jinhua Qinggan Granules combined with ribavirin injection in treatment of viral pneumonia
Objective To observe the efficacy of Jinhua Qinggan Granules combined with ribavirin injection in treatment of viral pneumonia(VP).Methods A total of 90 VP cases were randomly divided into study group and control group,with 45 cases in each group.Control group was treated with ribavirin injection,while study group was treated with Jinhua Qinggan Granules on the basis of control group.The two groups were compared in terms of efficacy,time to disappearance of symptoms and signs,symptom severity,clinical pulmonary infection score(CPIS)and chest X-ray absorption score,white blood cell count(WBC)and high-sensitivity C-reactive protein(hs-CRP)concentration,and the proportion of T lymphocytes,NK cells(CD3+ratio,CD4+ratio,CD8+ratio,CD4+/CD8+,and NK ratio and the gut bacteria count)before and after treatment.Results After treatment,the total effective rate of study group was higher than that of control group(P＜0.05);the time of body temperature recovery,cough disappearance,pulmonary rales disappearance and viral nucleic acid conversion time in study group were shorter than those in control group(P＜0.05);the symptom severity,CPIS and chest X-ray absorption scores,WBC and hs-CRP levels,CD81 ratio,Enterococcal and Enterobacteriaceae gene copies in both groups were lower than those before treatment,and were lower in study group than those in control group(P＜0.05);the proportion of CD3+,CD4+,CD4+/CD8+,NK,Bifidobacterium and Lactobacillus gene copies in both groups were higher than those before treatment,and were higher in study group than those in control group(P＜0.05).Conclusion Jinhua Qinggan Granules combined with ribavirin injection has a significant curative effect in treatment of VP,which can promote the resolution of symptoms and signs,reduce the severity of symptoms,inhibit inflammation,improve immunity,and regulate the number of intestinal bacteria.
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