Effect analysis of tonifying kidney,invigorating spleen,promoting diuresis and removing turbidity therapy on diabetes nephropathy
Objective To observe the application effect of tonifying kidney,invigorating spleen,promoting diuresis and removing turbidity therapy in patients with diabetes nephropathy(DN).Methods 120 patients with DN were randomly divided into observation group and control group,with 60 cases each.After basic treatment,control group was treated with tonifying qi,nourishing yin,promoting blood circulation,and removing blood stasis therapy,while observation group was treated with tonifying kidney,invigorating spleen,promoting diuresis and removing turbidity therapy.Comparing the curative effect and inflammatory response indicators,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),blood glucose indicators fasting blood glucose(FPG),glycated hemoglobin(HbA1c),postprandial 2-hour blood glucose(2 hPG),renal function indicators blood creatinine(SCR),cystatin C(CysC),urinary albumin(mAlb),urea nitrogen(BUN),glomerular filtration rate(eGFR),oxidative response indicators superoxide dismutase(SOD),malondialdehyde(MDA),total anti-oxidative capacity(T-AOC),immune function indicators CD3+,CD4+,CD8+,CD4+/CD8+;simultaneously conducting monitoring of gut microbiota to identify characteristic differences in microbiota.Results After treatment,the total clinical treatment effectiveness rate of observation group was higher than that of control group(P＜0.05);TNF-a,CRP,IL-6,FPG,HbA1c,2hPG,mAlb,BUN,SCr,CysC,MDA,and CD8+in both groups were all lower than those before treatment(P＜0.05),and were all lower in observation group than those in control group(P＜0.05),while Bifidobacterium,Escherichia coli,Lactobacillus,Bacteroides,Enterococcus,B/E value,eGFR,SOD,T-AOC,CD3+,CD4+,CD4+/CD8+in both groups were all higher than those before treatment(P＜0.05),and were all higher in observation group than those in control group(P＜0.05).Conclusion Tonifying kidney,invigorating spleen,promoting diuresis and removing turbidity therapy has better effect,which can effectively improve the condition,blood sugar level and renal function of patients with DN.The mechanism of action is regulating intestinal flora,improving inflammation,and oxidativing stress and immunity.
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