Efficacy of LivminTablets in treatment of menopausal syndrome after gynecological malignancy
Objective To observe the efficacy of Livmin Tablets in treatment of menopausal syndrome(PMSGM)after gynecologic malignancy.Methods A total of 120 PMSGM patients were randomly divided into study group and control group,with 60 cases each.Control group was treated with Tibolone Tablets,and study group was treated with Livmin Tablets.The total effective response rate before and after treatment,the levels of modified Kupperman(KI),menopausal quality of life scale(MENQOL),anxiety and depression self-rating scale(SAS,SDS),estradiol(E2)and luteinizing hormone(LH),β-collagen degradation products(β-CTx),type I procollagen aminoterminal propeptide(PINP),and abnormal reactions during treatment in the two groups were compared.Results After treatment,the effective response rate of study group was higher than that of control group(P＜0.05);on the 2nd and 4th months of treatment,KI score of study group was higher than that of control group(P＜0.05);E2 levels in both groups were higher than those before treatment,and was higher in study group than that in control group;MENQOL4 dimensions,SAS and SDS,LH,β-CTx and PIMP levels in both groups were lower than those before treatment,and were lower in study group than those in control group(P＜0.05);during the treatment,telectrocardiogram and liver and kidney function were rechecked,and no abnormalities were found,and there were no complaints of discomfort during the follow-up.Conclusion Livmin Tablets can significantly alleviate the symptoms,anxiety and depression of PMSGM patients,regulate the level of sex hormones and bone metabolism,improve the quality of life,and has high short-term safety and less adverse reactions.
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