Lianhua Qingwen Granules combined with bacterial lysate in treatment of recurrent respiratory tract infections in children
Objective To observe the efficacy of Lianhua Qingwen Granules combined with bacterial lysate(BL)in treatment of children with recurrent respiratory tract infections(CRRI).Methods A total of 125 CRRI cases were randomly divided into study group(63 cases)and control group(62 cases).Control group was treated with BL,and study group was treated with Lianhua Qingwen Granules on the basis of control group.The clinical efficacy,the number of CRRI occurrences,recovery indexes,interleukin-4(IL-4),IL-10,IL-12,interferon-y(IFN-γ),immunoglobulin G(IgG),IgM,IgA,IgE,amyloid A(SAA)and C-reactive protein(CRP)contents were compared between the two groups.Results After treatment,the total effective rate of study group was higher than that of control group(P＜0.05);the number of CRRI occurrences in study group at 3 months,6 months and 1 year after treatment was lower than that in control group(P＜0.05);the time of fever reduction,cough disappearance and lung rales in study group were shorter than those in control group(P＜0.05);the contents of IL-4,IL-10,IgE,SAA and CRP in both groups were lower than those before treatment,and the contents of IL-12,IFN-γ,IgG,IgM and IgA were higher than those before treatment,the above indexes in study group were siperior to those in control group(P＜05).Conclusion Lianhua Qingwen Granules combined with BL has significant efficacy in treatment of CRRI,it can reduce the number of attacks,promote recovery,regulate humoral immunity and cellular immunity,and reduce IgE and inflammatory cytokine contents.
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