Bushen Xiezhuo Formula improving inflammation and fibrosis of renal tissue in hyperuric acid nephropathy ameliorated by inhibiting NLRP3 inflammatory vesicle activation
Objective To observe the effect of Bushenxiezhuo Formula(BSXZF)to improve the physiological and bio-chemical indexes,renal inflammation and fibrosis in hyperuric acid nephropathy(HN).Methods Male C57BL/6 mice were randomly divided into normal group,model group,BSXZF group and the Simiaosan(SMS)group.Hypoadenine and potassium oxybate suspension was used for modelling,and BSXZF and Simiaosan aqueous decoction were used for intervention at the same time.Results BSXZF can improve the symptoms of renal yang deficiency in HN mice;it has different degrees of improvement on the inflammatory and fibrotic lesions in the kidney tissues of HN mice;and the expression of inflammation-related factors in the kidney tissues of mice was reduced.Conclusion BSXZF can significantly improve the inflammatory lesions in the kidneys,inhibit the activation of NLRP3 inflammatory vesicles and reduce the expression of pro-inflammatory factors in the kidneys.It can significantly improve the renal fibrosis lesions in HN mice and reduce the expression of fibrosis-related factors in renal tissues.
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